Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK9 | P50750 | 6/20 | 0.55 |
| ▸ | CDK2 | P24941 | 5/20 | 0.55 |
| ▸ | MET | P08581 | 1/20 | 0.55 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.52 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.52 |
| ▸ | ACHE | P22303 | 2/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | PLK1 | P53350 | 1/20 | 0.46 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 2/20 | 0.46 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.46 |
| ▸ | USP8 | P40818 | 2/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | GABRP | O00591 | 1/20 | 0.43 |
| ▸ | GABRD | O14764 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28848479 | 0.88 | PARP1 (0.52) | CDK9CDK2METCCNT1CCNA2 | |
| SCHEMBL28848486 | 0.85 | CDK9 (0.51) | CDK9CDK2METCCNT1CCNA2 | |
| SCHEMBL28848495 | 0.84 | CDK2 (0.41) | CDK9CDK2METCCNT1CCNA2 | |
| SCHEMBL29195639 | 0.84 | CDK2 (0.41) | CDK9CDK2METCCNT1CCNA2 | |
| SCHEMBL28848493 | 0.84 | CDK2 (0.42) | CDK9CDK2METCCNT1CCNA2 | |
| SCHEMBL28848659 | 0.84 | ACHE (0.67) | CDK9CDK2METCCNT1CCNA2 | |
| SCHEMBL28848526 | 0.80 | ACHE (0.60) | CDK9CDK2CCNT1CCNA2ACHE | |
| SCHEMBL28848656 | 0.79 | ACHE (0.51) | CDK9CDK2METCCNT1CCNA2 | |
| SCHEMBL28848654 | 0.78 | KDM5A (0.52) | CDK9CDK2METCCNT1CCNA2 | |
| SCHEMBL21335354 | 0.77 | ACHE (0.77) | CDK9CDK2METCCNT1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114957182-B | USP8 inhibitor containing flavone skeleton structure and application thereof | 中国药科大学 | 2024-03-15 | — | — | CN | disclosed |
| CN-114957182-A | USP8 inhibitor containing flavone skeleton structure and application thereof | 中国药科大学 | 2022-08-30 | — | — | CN | disclosed |