Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK9 | P50750 | 9/20 | 0.51 |
| ▸ | CDK2 | P24941 | 7/20 | 0.51 |
| ▸ | MET | P08581 | 1/20 | 0.51 |
| ▸ | USP8 | P40818 | 7/20 | 0.48 |
| ▸ | CCNT1 | O60563 | 8/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.46 |
| ▸ | CDK4 | P11802 | 1/20 | 0.46 |
| ▸ | CCND1 | P24385 | 1/20 | 0.46 |
| ▸ | CDK7 | P50613 | 1/20 | 0.46 |
| ▸ | CCNH | P51946 | 1/20 | 0.46 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.46 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28848512 | 0.87 | USP8 (0.62) | CDK9CDK2USP8CCNT1CCNA2 | |
| SCHEMBL28848489 | 0.85 | CDK9 (0.55) | CDK9CDK2METUSP8CCNT1 | |
| SCHEMBL28848530 | 0.79 | USP8 (0.54) | CDK9CDK2METUSP8CCNT1 | |
| SCHEMBL28848479 | 0.74 | PARP1 (0.52) | CDK9CDK2METUSP8CCNT1 | |
| SCHEMBL28848511 | 0.73 | USP8 (0.70) | CDK9CDK2METUSP8CCNT1 | |
| SCHEMBL28848519 | 0.72 | USP8 (0.55) | CDK9CDK2METUSP8CCNT1 | |
| SCHEMBL22667243 | 0.71 | USP8 (0.77) | CDK9CDK2USP8CCNT1CCNA2 | |
| SCHEMBL21335354 | 0.71 | ACHE (0.77) | CDK9CDK2METCCNT1CCNA2 | |
| SCHEMBL29195639 | 0.71 | CDK2 (0.41) | CDK9CDK2METCCNT1CCNA2 | |
| SCHEMBL28848493 | 0.70 | CDK2 (0.42) | CDK9CDK2METCCNT1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114957182-B | USP8 inhibitor containing flavone skeleton structure and application thereof | 中国药科大学 | 2024-03-15 | — | — | CN | disclosed |
| CN-114957182-A | USP8 inhibitor containing flavone skeleton structure and application thereof | 中国药科大学 | 2022-08-30 | — | — | CN | disclosed |