Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP8 | P40818 | 12/20 | 0.54 |
| ▸ | PARP1 | P09874 | 3/20 | 0.49 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.49 |
| ▸ | CDK9 | P50750 | 4/20 | 0.49 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.49 |
| ▸ | CDK2 | P24941 | 3/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.47 |
| ▸ | CDK4 | P11802 | 1/20 | 0.47 |
| ▸ | CCND1 | P24385 | 1/20 | 0.47 |
| ▸ | CDK7 | P50613 | 1/20 | 0.47 |
| ▸ | CCNH | P51946 | 1/20 | 0.47 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.47 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.47 |
| ▸ | CCNC | P24863 | 1/20 | 0.46 |
| ▸ | CDK8 | P49336 | 1/20 | 0.46 |
| ▸ | MET | P08581 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28848479 | 0.89 | PARP1 (0.52) | USP8PARP1PARP2CDK9CCNT1 | |
| SCHEMBL28848486 | 0.79 | CDK9 (0.51) | USP8CDK9CCNT1CDK2CCNA2 | |
| SCHEMBL28848489 | 0.77 | CDK9 (0.55) | USP8PARP1PARP2CDK9CCNT1 | |
| SCHEMBL28848511 | 0.75 | USP8 (0.70) | USP8PARP1PARP2CDK9CCNT1 | |
| SCHEMBL28848498 | 0.74 | USP8 (0.77) | USP8CDK9CCNT1CDK2CCNA2 | |
| SCHEMBL22667247 | 0.72 | USP8 (0.78) | USP8CDK9CCNT1CDK2CCNA2 | |
| SCHEMBL28848534 | 0.71 | USP8 (0.98) | USP8CDK9CCNT1CDK2CCNA2 | |
| SCHEMBL22667235 | 0.71 | USP8 (1.00) | USP8CDK9CCNT1CDK2CCNA2 | |
| SCHEMBL28848519 | 0.70 | USP8 (0.55) | USP8PARP1PARP2CDK9CCNT1 | |
| SCHEMBL22667252 | 0.69 | USP8 (0.92) | USP8CDK9CCNT1CDK2CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114957182-B | USP8 inhibitor containing flavone skeleton structure and application thereof | 中国药科大学 | 2024-03-15 | — | — | CN | disclosed |
| CN-114957182-A | USP8 inhibitor containing flavone skeleton structure and application thereof | 中国药科大学 | 2022-08-30 | — | — | CN | disclosed |