Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20535567 | 0.78 | LMNA (0.44) | MAPTLMNAALDH1A1SMN1; SMN2HTT | |
| SCHEMBL8191430 | 0.78 | ALDH1A1 (0.39) | MAPTLMNAALDH1A1HTTPOLB | |
| SCHEMBL4314450 | 0.78 | SMN1; SMN2 (0.53) | MAPTAKR1C3AKR1C2LMNAALDH1A1 | |
| SCHEMBL30288984 | 0.76 | LMNA (0.43) | MAPTLMNAALDH1A1PKMMEN1 | |
| SCHEMBL18174193 | 0.76 | LMNA (0.51) | MAPTLMNAALDH1A1HCAR3PKM | |
| SCHEMBL8192345 | 0.76 | LMNA (0.41) | MAPTLMNAALDH1A1SMN1; SMN2HTT | |
| SCHEMBL16537127 | 0.76 | LMNA (0.44) | MAPTLMNAALDH1A1SMN1; SMN2HTT | |
| SCHEMBL28848976 | 0.75 | LMNA (0.42) | MAPTLMNAALDH1A1SMN1; SMN2HCAR3 | |
| SCHEMBL3728013 | 0.75 | ALDH1A1 (0.46) | MAPTLMNAALDH1A1HTTPOLB | |
| SCHEMBL8900469 | 0.75 | HCAR3 (0.57) | MAPTAKR1C3AKR1C2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111377907-B | Polysubstituted phenylamino pyrimidine derivative and preparation method and application thereof | 杭州百新生物医药科技有限公司 | 2023-03-28 | — | — | CN | disclosed |
| CN-111377907-A | Polysubstituted phenylamino pyrimidine derivative and preparation method and application thereof | 杭州百新生物医药科技有限公司 | 2020-07-07 | — | — | CN | disclosed |
| WO-2020135507-A1 | POLYSUBSTITUTED ANILINOPYRIMIDINE DERIVATIVE AND PREPARATION METHOD AND APPLICATION THEREOF | 杭州百新生物医药科技有限公司 | 2020-07-02 | — | — | WO | disclosed |