Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 4/20 | 0.36 |
| ▸ | KCNQ3 | O43525 | 4/20 | 0.34 |
| ▸ | KCNQ2 | O43526 | 4/20 | 0.34 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
| ▸ | SSTR3 | P32745 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | VNN1 | O95497 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2884930 | 1.00 | AR (0.36) | ARKCNQ3KCNQ2PLA2G7HSD11B1 | |
| SCHEMBL2882433 | 0.81 | AR (0.32) | ARKCNQ3KCNQ2HSD11B1CES2 | |
| SCHEMBL4066477 | 0.73 | CES2 (0.46) | KCNQ3KCNQ2PLA2G7CES2CES1 | |
| SCHEMBL2880794 | 0.73 | MCHR1 (0.40) | KCNH2MCHR1 | |
| SCHEMBL4068874 | 0.61 | CES2 (0.44) | KCNQ3KCNQ2PLA2G7CES2CES1 | |
| SCHEMBL28004400 | 0.60 | SERPINE1 (0.56) | KCNQ3KCNQ2PLA2G7HSD11B1CES2 | |
| SCHEMBL28266834 | 0.58 | SERPINE1 (0.51) | PLA2G7HSD11B1CES2CES1RAB9A | |
| SCHEMBL21448795 | 0.58 | HSD11B1 (0.60) | HSD11B1CES2CES1RAB9AMEN1 | |
| Ethylene Glycol SCHEMBL28725409 | 0.56 | ALDH1A1 (0.44) | PLA2G7CES2CES1RAB9A | |
| SCHEMBL48607 | 0.56 | ALDH1A1 (0.52) | PLA2G7CES2CES1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100324049-A1 | DIARYL KETIMINE DERIVATIVE HAVING ANTAGONISM AGAINST MELANIN-CONCENTRATING HORMONE RECEPTOR | MSD K.K. (JP) | 2010-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100324049-A1 | DIARYL KETIMINE DERIVATIVE HAVING ANTAGONISM AGAINST MELANIN-CONCENTRATING HORMONE RECEPTOR | MC1R, MCHR1, MCHR2 | AR 47/4885KCNQ3 987/4885KCNQ2 1125/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.