SCHEMBL28849453

SCHEMBL28849453

O[C@]1(c2ccccc2F)CCCC[C@@H]1Cc1ccccn1

nearest known ligand 0.41

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.41
TRPA1 O75762 3/20 0.40
RAB9A P51151 2/20 0.40
MAPT P10636 1/20 0.39
SLC6A9 P48067 1/20 0.38
P2RX7 Q99572 1/20 0.35
HPGD P15428 2/20 0.35
RECQL P46063 1/20 0.35
CHRM1 P11229 1/20 0.35
HDAC4 P56524 1/20 0.35
NPC1 O15118 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28849431 0.83 TRPA1 (0.41) TSHRTRPA1RAB9AMAPTSLC6A9
SCHEMBL28849438 0.82 MAPT (0.42) TRPA1MAPTHPGDRECQLCHRM1
SCHEMBL29950355 0.80 SLC6A2 (0.44) TSHRTRPA1RAB9AMAPTSLC6A9
SCHEMBL28849414 0.80 SLC6A2 (0.44) TSHRTRPA1RAB9AMAPTSLC6A9
SCHEMBL28849440 0.78 TRPA1 (0.48) TRPA1RAB9AMAPTSLC6A9HPGD
SCHEMBL28849430 0.78 MAPT (0.39) TRPA1MAPTSLC6A9HPGDRECQL
SCHEMBL28849437 0.78 MAPT (0.39) TRPA1MAPTHPGDRECQLCHRM1
SCHEMBL28849423 0.77 CHRM2 (0.40) TRPA1RAB9AMAPTSLC6A9HPGD
SCHEMBL28849416 0.77 MAPT (0.43) TSHRTRPA1RAB9AMAPTHPGD
SCHEMBL28849415 0.76 SLC6A4 (0.42) CHRM1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115108875-B Nitrogen-containing heteroarene chiral cyclic alcohol constructed by asymmetric catalysis of visible light, and preparation method and application thereof 河南师范大学 2023-07-04 CN disclosed
CN-115108875-A Nitrogen-containing heteroarene chiral cyclic alcohol constructed by visible light asymmetric catalysis, and preparation method and application thereof 河南师范大学 2022-09-27 CN disclosed