Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.86 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.86 |
| ▸ | CDC7 | O00311 | 6/20 | 0.58 |
| ▸ | DBF4 | Q9UBU7 | 6/20 | 0.58 |
| ▸ | GAA | P10253 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL289139 | 1.00 | KDM4E (0.86) | KDM4EALDH1A1CDC7DBF4GAA | |
| SCHEMBL290132 | 0.92 | KDM4E (1.00) | KDM4EALDH1A1CDC7DBF4GAA | |
| SCHEMBL290278 | 0.86 | KDM4E (0.66) | KDM4EALDH1A1CDC7DBF4LMNA | |
| SCHEMBL290099 | 0.85 | KDM4E (0.81) | KDM4EALDH1A1CDC7DBF4GAA | |
| SCHEMBL288994 | 0.84 | KDM4E (0.80) | KDM4EALDH1A1CDC7DBF4GAA | |
| SCHEMBL290101 | 0.84 | ALDH1A1 (0.64) | KDM4EALDH1A1CDC7DBF4GAA | |
| SCHEMBL289147 | 0.84 | KDM4E (0.67) | KDM4EALDH1A1CDC7DBF4LMNA | |
| SCHEMBL289644 | 0.84 | KDM4E (0.74) | KDM4EALDH1A1CDC7DBF4GAA | |
| SCHEMBL289613 | 0.84 | KDM4E (0.78) | KDM4EALDH1A1CDC7DBF4GAA | |
| SCHEMBL289916 | 0.84 | KDM4E (0.71) | KDM4EALDH1A1CDC7DBF4GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427447-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | Pike Pharma GmbH (CH) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010128163-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | PIKE PHARMA GMBH (CH) | 2010-11-11 | — | — | WO | disclosed |