Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.81 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.81 |
| ▸ | CDC7 | O00311 | 8/20 | 0.69 |
| ▸ | DBF4 | Q9UBU7 | 8/20 | 0.69 |
| ▸ | TRPM8 | Q7Z2W7 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.53 |
| ▸ | CRHBP | P24387 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL290249 | 0.92 | KDM4E (0.76) | KDM4EALDH1A1CDC7DBF4TRPM8 | |
| SCHEMBL290132 | 0.90 | KDM4E (1.00) | KDM4EALDH1A1CDC7DBF4TRPM8 | |
| SCHEMBL288534 | 0.85 | KDM4E (0.86) | KDM4EALDH1A1CDC7DBF4TRPM8 | |
| SCHEMBL289139 | 0.85 | KDM4E (0.86) | KDM4EALDH1A1CDC7DBF4TRPM8 | |
| SCHEMBL288994 | 0.84 | KDM4E (0.80) | KDM4EALDH1A1CDC7DBF4TRPM8 | |
| SCHEMBL289704 | 0.83 | KDM4E (0.79) | KDM4EALDH1A1LMNAGAANPC1 | |
| SCHEMBL289229 | 0.83 | CDC7 (0.73) | KDM4EALDH1A1CDC7DBF4TRPM8 | |
| SCHEMBL892889 | 0.83 | CDC7 (0.77) | KDM4EALDH1A1CDC7DBF4TRPM8 | |
| SCHEMBL1316281 | 0.83 | CDC7 (0.77) | KDM4EALDH1A1CDC7DBF4TRPM8 | |
| SCHEMBL290007 | 0.82 | KDM4E (0.76) | KDM4EALDH1A1CDC7DBF4TRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427447-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | Pike Pharma GmbH (CH) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010128163-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | PIKE PHARMA GMBH (CH) | 2010-11-11 | — | — | WO | disclosed |