SCHEMBL28854331

SCHEMBL28854331

COc1cccc(-c2ccccc2CBr)c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR7 P34969 1/20 0.51
ABCB1 P08183 1/20 0.48
ABCC1 P33527 1/20 0.48
BRD4 O60885 1/20 0.46
CYP1A2 P05177 3/20 0.45
CYP3A4 P08684 3/20 0.45
CYP2D6 P10635 3/20 0.45
CYP2C9 P11712 3/20 0.45
CYP2C19 P33261 3/20 0.45
CLK4 Q9HAZ1 2/20 0.45
CYP1A1 P04798 2/20 0.45
CYP2E1 P05181 2/20 0.45
CYP2C8 P10632 2/20 0.45
CYP2A6 P11509 2/20 0.45
CYP4B1 P13584 2/20 0.45
CYP2B6 P20813 2/20 0.45
CYP3A5 P20815 2/20 0.45
CYP2A7 P20853 2/20 0.45
CYP3A7 P24462 2/20 0.45
CYP2F1 P24903 2/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30728873 0.87 HTR7 (0.43) HTR7ABCB1ABCC1BRD4CYP1A2
SCHEMBL8279410 0.83 MGAT2 (0.57) HTR7ABCB1ABCC1BRD4CYP1A2
Hydrochloric Acid SCHEMBL12490805 0.82 MGAT2 (0.56) HTR7ABCB1ABCC1BRD4CYP1A2
SCHEMBL2020140 0.82 ABL1 (0.59) ABCB1BRD4CYP1A2CYP3A4CYP2D6
SCHEMBL1715907 0.81 IDO1 (0.54) HTR7ABCB1ABCC1BRD4LMNA
SCHEMBL8281062 0.81 HTR7 (0.52) HTR7ABCB1ABCC1BRD4CYP1A2
SCHEMBL952649 0.81 HTR7 (0.49) HTR7ABCB1ABCC1BRD4CYP1A2
SCHEMBL17295958 0.81 ABCB1 (0.52) HTR7ABCB1ABCC1BRD4LMNA
SCHEMBL6048529 0.81 BACE1 (0.58) HTR7ABCB1ABCC1CYP1A2CYP3A4
Hydrochloric Acid SCHEMBL6048554 0.80 BACE1 (0.57) HTR7ABCB1ABCC1CYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107628925-A A kind of preparation method of 2 phenyl halogenation methylbenzene and its derivative 中国石油化工股份有限公司 2018-01-26 CN disclosed