Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 5/20 | 0.49 |
| ▸ | NCF1 | P14598 | 1/20 | 0.48 |
| ▸ | GAK | O14976 | 1/20 | 0.43 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.43 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.43 |
| ▸ | STK16 | O75716 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.43 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.43 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.43 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 8/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CCNC | P24863 | 2/20 | 0.41 |
| ▸ | CDK8 | P49336 | 2/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28856475 | 0.86 | ALK (0.46) | SLC22A12NCF1GAKEPHB6RIPK2 | |
| SCHEMBL29955009 | 0.80 | PARP1 (0.42) | RIPK2HTTLMNAALDH1A1MAPT | |
| SCHEMBL29778053 | 0.80 | NR4A2 (0.58) | GAKRIPK2COQ8ANLKLMNA | |
| SCHEMBL18949705 | 0.79 | CDK8 (0.45) | SLC22A12GAKRIPK2ACVR1AAK1 | |
| SCHEMBL18305649 | 0.76 | LMNA (0.59) | SLC22A12NCF1GAKRIPK2COQ8A | |
| SCHEMBL360254 | 0.76 | SLC22A12 (0.51) | SLC22A12NCF1GAKEPHB6RIPK2 | |
| SCHEMBL741042 | 0.76 | SLC22A12 (0.53) | SLC22A12NCF1GAKEPHB6RIPK2 | |
| SCHEMBL29896761 | 0.75 | SLC22A12 (0.51) | SLC22A12NCF1GAKEPHB6RIPK2 | |
| SCHEMBL14690611 | 0.75 | SLC22A12 (0.51) | SLC22A12NCF1GAKEPHB6RIPK2 | |
| SCHEMBL29843833 | 0.75 | GAK (0.46) | SLC22A12GAKRIPK2COQ8ANLK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109608432-B | Thiophene derivatives as URAT1 inhibitors | 江苏艾立康医药科技有限公司 | 2022-10-11 | — | — | CN | disclosed |