Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 2/20 | 0.45 |
| ▸ | CCNC | P24863 | 1/20 | 0.45 |
| ▸ | GAK | O14976 | 1/20 | 0.43 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 7/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.37 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.36 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.36 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.36 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29778037 | 0.86 | FERMT2 (0.45) | CDK8CCNCGAKIDO1ACVR1 | |
| SCHEMBL22812983 | 0.82 | PARP1 (0.43) | CDK8CCNCGAKSLC22A12PARP1 | |
| SCHEMBL16156640 | 0.81 | GAK (0.46) | CDK8CCNCGAKSLC22A12PARP1 | |
| SCHEMBL29955009 | 0.80 | PARP1 (0.42) | PARP1HTTNR4A2RIPK2 | |
| SCHEMBL29778053 | 0.80 | NR4A2 (0.58) | CDK8CCNCGAKPARP1NR4A2 | |
| SCHEMBL16010143 | 0.79 | GAK (0.37) | CDK8CCNCGAKSLC22A12PARP1 | |
| SCHEMBL28856552 | 0.79 | SLC22A12 (0.49) | CDK8CCNCGAKSLC22A12HTT | |
| SCHEMBL18305649 | 0.76 | LMNA (0.59) | GAKSLC22A12RIPK2 | |
| SCHEMBL591523 | 0.76 | CDK8 (0.49) | CDK8CCNCGAKSLC22A12PARP1 | |
| SCHEMBL14300355 | 0.76 | SMN1; SMN2 (0.56) | CDK8CCNCGAKSLC22A12PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110092750-B | Pentafluoro sulfanyl substituted amide compound, preparation method and application thereof in medicine | 北京诺诚健华医药科技有限公司 | 2023-07-21 | — | — | CN | disclosed |
| CN-112334458-B | 3-indazolinone compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-11-08 | — | — | CN | disclosed |
| CN-109608432-B | Thiophene derivatives as URAT1 inhibitors | 江苏艾立康医药科技有限公司 | 2022-10-11 | — | — | CN | disclosed |
| US-11389445-B2 | Pentafluorosulfanyl-substituted amide derivatives, preparation methods thereof and medical uses thereof | BEIJING INNOCARE PHARMA TECH CO., LTD. (CN) | 2022-07-19 | — | — | US | disclosed |
| US-20210221808-A1 | 3-OXAZOLINONE COMPOUND, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL APPLICATION THEREOF | BEIJING INNOCARE PHARMA TECH CO., LTD. (CN) | 2021-07-22 | — | — | US | disclosed |
| US-20210046069-A1 | PENTAFLUOROSULFANYL-SUBSTITUTED AMIDE DERIVATIVES, PREPARATION METHODS THEREOF AND MEDICAL USES THEREOF | BEIJING INNOCARE PHARMA TECH CO., LTD. (CN) | 2021-02-18 | — | — | US | disclosed |
| US-20210047290-A1 | SPIRO COMPOUND AS INDOLEAMINE-2,3-DIOXYGENASE INHIBITOR | SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, CHINESE ACADEMY OF SCIENCES (CN) | 2021-02-18 | — | — | US | disclosed |
| CN-112334458-A | 3-indazolinone compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2021-02-05 | — | — | CN | disclosed |
| CN-110105275-B | Amide derivatives, preparation method and medical application thereof | 上海海雁医药科技有限公司 | 2020-12-29 | — | — | CN | disclosed |
| EP-3747865-A1 | PENTAFLUOROSULFANYL-SUBSTITUTED AMIDE COMPOUND, PREPARATION METHOD THEREFOR, AND MEDICAL APPLICATION THEREOF | Beijing InnoCare Pharma Tech Co., Ltd. (CN) | 2020-12-09 | — | — | EP | disclosed |
| EP-3704095-A1 | MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2020-09-09 | — | — | EP | disclosed |
| US-20200239420-A1 | MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-07-30 | — | — | US | disclosed |
| US-20200239420-A1 | MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-07-30 | — | — | US | disclosed |
| CN-111263752-A | Modulators of indoleamine2,3-dioxygenase | 葛兰素史克知识产权开发有限公司 | 2020-06-09 | — | — | CN | disclosed |
| CN-110540521-A | Octahydro pentalene compound, preparation method and application thereof in medicine and pharmacology | BEIJING INNOCARE PHARMA TECH CO LTD | 2019-12-06 | — | — | CN | disclosed |
| WO-2019228170-A1 | OCTAHYDROPENTENE COMPOUND, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL APPLICATION THEREOF | 北京诺诚健华医药科技有限公司 (CN) | 2019-12-05 | — | — | WO | disclosed |
| WO-2019158051-A1 | SPIRO COMPOUND AS INDOLEAMINE-2,3-DIOXYGENASE INHIBITOR | 中国科学院上海有机化学研究所 | 2019-08-22 | — | — | WO | disclosed |
| US-20170281773-A1 | BET BROMODOMAIN INHIBITORS AND THERAPEUTIC METHODS USING THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2017-10-05 | — | — | US | disclosed |
| US-9675697-B2 | BET bromodomain inhibitors and therapeutic methods using the same | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2017-06-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210047290-A1 | SPIRO COMPOUND AS INDOLEAMINE-2,3-DIOXYGENASE INHIBITOR | IDO1, IDO2, TPH1 | CDK8 1321/4885CCNC 3149/4885GAK 1891/4885 |
| US-20210221808-A1 | 3-OXAZOLINONE COMPOUND, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL APPLICATION THEREOF | IDO1, IDO2, INMT | CDK8 1750/4885CCNC 4183/4885GAK 2483/4885 |
| US-20210046069-A1 | PENTAFLUOROSULFANYL-SUBSTITUTED AMIDE DERIVATIVES, PREPARATION METHODS THEREOF AND MEDICAL USES THEREOF | IDO1, IDO2, KYNU | CDK8 2456/4885CCNC 4786/4885GAK 3859/4885 |
| US-20200239420-A1 | MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE | IDO1, IDO2, TPH1 | CDK8 1845/4885CCNC 3934/4885GAK 3215/4885 |
| US-20170281773-A1 | BET BROMODOMAIN INHIBITORS AND THERAPEUTIC METHODS USING THE SAME | BRD4, BRDT, BRD3 | CDK8 300/4885CCNC 1178/4885GAK 886/4885 |
| US-11389445-B2 | Pentafluorosulfanyl-substituted amide derivatives, preparation methods thereof and medical uses thereof | IDO1, IDO2, KYNU | CDK8 2456/4885CCNC 4786/4885GAK 3859/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.