Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | TP53 | P04637 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | CA1 | P00915 | 4/20 | 0.56 |
| ▸ | CA2 | P00918 | 4/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | BACE1 | P56817 | 2/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TLR2 | O60603 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1547301 | 0.84 | CA1 (0.52) | MAPTTP53KDM4EMAPK1ALDH1A1 | |
| SCHEMBL9929133 | 0.84 | MAPT (0.55) | MAPTTP53KDM4EMAPK1ALDH1A1 | |
| SCHEMBL15677700 | 0.82 | MAPT (0.57) | MAPTTP53KDM4EMAPK1ALDH1A1 | |
| SCHEMBL3828263 | 0.82 | MAPT (0.57) | MAPTTP53KDM4EMAPK1ALDH1A1 | |
| SCHEMBL743608 | 0.82 | ALDH1A1 (0.57) | MAPTTP53KDM4EMAPK1ALDH1A1 | |
| SCHEMBL15677702 | 0.79 | KDM4E (0.54) | MAPTTP53KDM4EMAPK1ALDH1A1 | |
| SCHEMBL28554988 | 0.77 | MAPT (0.52) | MAPTTP53KDM4EMAPK1ALDH1A1 | |
| SCHEMBL24440800 | 0.76 | CA12 (0.61) | MAPTTP53KDM4EMAPK1ALDH1A1 | |
| SCHEMBL28870792 | 0.76 | XDH (0.53) | MAPTTP53KDM4EMAPK1ALDH1A1 | |
| SCHEMBL28870795 | 0.76 | XDH (0.53) | MAPTTP53KDM4EMAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107849025-A | For treating the CHK1/2 inhibitor of neuroblastoma and/or soft tissue sarcoma | 伊莱利利公司 | 2018-03-27 | — | — | CN | disclosed |