SCHEMBL28859552

SCHEMBL28859552

CS(=O)(=O)Oc1c(F)c(F)cc(C(F)(F)F)c1F

nearest known ligand 0.37

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 4/20 0.37
PTGS2 P35354 1/20 0.32
ALDH1A1 P00352 1/20 0.32
CA1 P00915 1/20 0.31
CA2 P00918 1/20 0.31
CA9 Q16790 1/20 0.31
AR P10275 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3742731 0.83 CA1 (0.41) ALDH1A1CA1CA2CA9
SCHEMBL9958259 0.75 CA12 (0.35) PTGS2ALDH1A1CA1CA2
SCHEMBL17356327 0.73 CA1 (0.35) KIF11PTGS2CA1CA2CA9
SCHEMBL17355698 0.72 SLC22A12 (0.40) KIF11AR
SCHEMBL17356397 0.72 SMN1; SMN2 (0.43) ALDH1A1CA1CA2CA9
SCHEMBL15453749 0.71 KMT2A (0.37) KIF11ALDH1A1
SCHEMBL585314 0.70 CA1 (0.56) CA1CA2CA9
SCHEMBL3749537 0.70 CES2 (0.40) PTGS2ALDH1A1CA1CA2CA9
SCHEMBL28860791 0.69 CA1 (0.42) CA1CA2CA9
SCHEMBL17356313 0.69 KIF11 (0.51) KIF11PTGS2ALDH1A1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105008378-B The manufacturing method of cross-coupling catalysts and aromatic compound 北兴化学工业株式会社 2018-05-18 CN disclosed