Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | IL2 | P60568 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2886677 | 0.90 | KDM4E (0.59) | KDM4EIL2HTTLMNAMAPT | |
| SCHEMBL20971905 | 0.90 | KDM4E (0.49) | KDM4EIL2HTTLMNAMAPT | |
| SCHEMBL18987369 | 0.86 | KDM4E (0.51) | KDM4EIL2HTTLMNAMAPT | |
| SCHEMBL9754434 | 0.83 | IL2 (0.46) | KDM4EIL2HTTLMNAMAPT | |
| SCHEMBL4165008 | 0.80 | KDM4E (0.51) | KDM4EIL2HTTLMNAMAPT | |
| SCHEMBL7223413 | 0.79 | KDM4E (0.47) | KDM4EIL2HTTLMNAMAPT | |
| SCHEMBL610146 | 0.78 | LMNA (0.43) | KDM4EIL2HTTLMNAMAPT | |
| SCHEMBL7219394 | 0.77 | KDM4E (0.46) | KDM4EIL2HTTLMNAMAPT | |
| SCHEMBL4160708 | 0.76 | KDM4E (0.47) | KDM4EMAPTALDH1A1HPGDCYP2D6 | |
| SCHEMBL4160704 | 0.76 | KDM4E (0.47) | KDM4EMAPTALDH1A1HPGDCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11807609-B2 | Deuterated compounds as immunomodulators | CHEMOCENTRYX, INC. (US) | 2023-11-07 | — | — | US | disclosed |
| US-8283373-B2 | Inhibitors of cytosolic phospholipase A2 | PFIZER INC. (US) | 2012-10-09 | — | — | US | disclosed |
| EP-1891006-B1 | INHIBITORS OF CYTOSOLIC PHOSPHOLIPASE A2 | WYETH LLC (US) | 2010-11-24 | — | — | EP | disclosed |
| EP-2248801-A1 | Inhibitors of cytosolic phospholipase a2 | Wyeth LLC (US) | 2010-11-10 | — | — | EP | disclosed |
| US-20100029645-A1 | Inhibitors of Cytosolic Phospholipase A2 | WYETH LLC | 2010-02-04 | — | — | US | disclosed |
| US-20100022536-A1 | Inhibitors of Cytosolic Phospholipase A2 | NOVARTIS AG (CH) | 2010-01-28 | — | — | US | disclosed |
| US-7557135-B2 | Inhibitors of cytosolic phospholipase A2 | WYETH (US) | 2009-07-07 | — | — | US | disclosed |
| EP-1891006-A2 | INHIBITORS OF CYTOSOLIC PHOSPHOLIPASE A2 | Wyeth a Corporation of the State of Delaware (US) | 2008-02-27 | — | — | EP | disclosed |
| US-20070004719-A1 | Inhibitors of cytosolic phospholipase A2 | WYETH (US) | 2007-01-04 | — | — | US | disclosed |
| WO-2006128142-A2 | INHIBITORS OF CYTOSOLIC PHOSPHOLIPASE A2 | WYETH (US) | 2006-11-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11807609-B2 | Deuterated compounds as immunomodulators | C3AR1, C5AR1, C5AR2 | KDM4E 3617/4885IL2 88/4885HTT 4047/4885 |
| US-20100022536-A1 | Inhibitors of Cytosolic Phospholipase A2 | PLA2G4B, PLA2G4A, PLA2G12A | KDM4E 3787/4885IL2 2863/4885HTT 4779/4885 |
| US-20100029645-A1 | Inhibitors of Cytosolic Phospholipase A2 | PLA2G4B, PLA2G4A, PLA2G12A | KDM4E 3787/4885IL2 2863/4885HTT 4779/4885 |
| US-20070004719-A1 | Inhibitors of cytosolic phospholipase A2 | PLA2G4B, PLA2G4A, PLA2G12A | KDM4E 3787/4885IL2 2863/4885HTT 4779/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.