Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | LPO | P22079 | 3/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | CMA1 | P23946 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19643992 | 0.89 | LMNA (0.46) | LMNAHTTALOX15TSHRPKM | |
| SCHEMBL28266159 | 0.87 | LMNA (0.44) | LMNAHTTALOX15TSHRPKM | |
| SCHEMBL28267508 | 0.85 | LMNA (0.48) | LMNAHTTALOX15TSHRPKM | |
| SCHEMBL28266102 | 0.76 | LMNA (0.50) | LMNAHTTALOX15TSHRPKM | |
| SCHEMBL28186297 | 0.75 | LMNA (0.51) | LMNAHTTALOX15TSHRPKM | |
| SCHEMBL20985759 | 0.73 | ROCK2 (0.55) | ROCK2 | |
| SCHEMBL20985824 | 0.72 | ROCK2 (0.60) | ROCK2 | |
| SCHEMBL20985807 | 0.72 | ROCK2 (0.59) | ROCK2 | |
| SCHEMBL17912991 | 0.71 | PKM (0.48) | LMNAHTTALOX15TSHRPKM | |
| SCHEMBL17912992 | 0.70 | PKM (0.79) | LMNAHTTALOX15TSHRPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109153663-A | Triazolones and Tetrazolones as ROCK Inhibitors | 百时美施贵宝公司 | 2019-01-04 | — | — | CN | disclosed |