Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ODC1 | P11926 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | BLM | P54132 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PLG | P00747 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4727982 | 0.79 | ODC1 (0.43) | ODC1LMNABLMKDM4EMAPT | |
| SCHEMBL3818403 | 0.76 | ALDH1A1 (0.35) | LMNATHRBKMT2AMEN1ALDH1A1 | |
| SCHEMBL23217861 | 0.75 | ODC1 (0.33) | ODC1LMNABLMKDM4EMAPT | |
| SCHEMBL997199 | 0.74 | ODC1 (0.48) | ODC1LMNABLMKDM4EMAPT | |
| SCHEMBL997201 | 0.74 | ODC1 (0.48) | ODC1LMNABLMKDM4EMAPT | |
| SCHEMBL997202 | 0.74 | ODC1 (0.48) | ODC1LMNABLMKDM4EMAPT | |
| SCHEMBL30496170 | 0.73 | ARG1 (0.31) | ARG1ARG2 | |
| SCHEMBL9501854 | 0.71 | ODC1 (0.61) | ODC1LMNABLMKDM4EMAPT | |
| SCHEMBL2115160 | 0.70 | ODC1 (0.48) | ODC1LMNABLMKDM4EMAPT | |
| SCHEMBL2587404 | 0.70 | ODC1 (0.48) | ODC1LMNABLMKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7722858-B2 | Prevention and treatment of atherosclerosis by reducing carbamylation of LDL or the effects of carbamylated LDL | BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (US) | 2010-05-25 | — | — | US | disclosed |
| US-7476551-B2 | Diagnosing atherosclerosis risk by measuring carbamylated low density lipoprotein levels | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (US) | 2009-01-13 | — | — | US | disclosed |
| WO-2007092625-A2 | PREVENTION AND TREATMENT OF ATHEROSCLEROSIS BY REDUCING CARBAMYLATION OF LDL OR THE EFFECTS OF CLDL | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (US) | 2007-08-16 | — | — | WO | disclosed |
| US-20060183245-A1 | Prevention and treatment of atherosclerosis by reducing carbamylation of LDL or the effects of carbamylated LDL | BIOVENTURES, LLC | 2006-08-17 | — | — | US | disclosed |
| US-20030045004-A1 | Prevention and treatment of atherosclerosis by reducing carbamylation of LDL or the effects of carbamylated LDL | VETERANS AFFAIRS, THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF | 2003-03-06 | — | — | US | disclosed |