SCHEMBL4727982

SCHEMBL4727982

N=C(N)NC(N)(CCCN)C(=O)O

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ODC1 P11926 2/20 0.43
LMNA P02545 2/20 0.41
BLM P54132 2/20 0.41
KDM4E B2RXH2 1/20 0.41
MAPT P10636 1/20 0.41
RAB9A P51151 1/20 0.41
PMP22 Q01453 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
GABRR3 A8MPY1 1/20 0.31
GABRP O00591 1/20 0.31
GABRD O14764 1/20 0.31
HDAC3 O15379 1/20 0.31
GABBR2 O75899 1/20 0.31
CYP1A2 P05177 1/20 0.31
THRB P10828 1/20 0.31
GABRA1 P14867 1/20 0.31
TSHR P16473 1/20 0.31
GABRB1 P18505 1/20 0.31
GABRG2 P18507 1/20 0.31
GABRR1 P24046 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8709507 0.84 FDPS (0.36) CYP1A2THRBKMT2AFDPS
Hydrochloric Acid SCHEMBL28434665 0.82 FDPS (0.35) CYP1A2THRBKMT2AFDPS
SCHEMBL6130815 0.81 ALOX15 (0.39) SMN1; SMN2CYP1A2KMT2A
SCHEMBL2886844 0.79 ODC1 (0.40) ODC1LMNABLMKDM4EMAPT
SCHEMBL1560751 0.79 MEN1 (0.41) LMNAKDM4ECYP1A2THRBGABRR1
SCHEMBL12006238 0.79 ALDH1A1 (0.33) LMNACYP1A2THRBKMT2AFDPS
SCHEMBL11708028 0.79 ALDH1A1 (0.33) LMNACYP1A2THRBKMT2AFDPS
SCHEMBL6130817 0.78 ALOX15 (0.44) SMN1; SMN2CYP1A2TSHRKMT2ANFKB1
SCHEMBL997202 0.76 ODC1 (0.48) ODC1LMNABLMKDM4EMAPT
SCHEMBL997201 0.76 ODC1 (0.48) ODC1LMNABLMKDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008033365-A2 AMINO ION RELEASING HYDROGEN BONDED MOLECULE SCHUTT STEVEN R (US) 2008-03-20 WO disclosed
US-20080064754-A1 Amino ion releasing hydrogen bonded molecule SCHUTT STEVEN R 2008-03-13 US disclosed