Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 5/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | ESPL1 | Q14674 | 1/20 | 0.33 |
| ▸ | CASP6 | P55212 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22576052 | 0.76 | KDM4E (0.55) | KDM4ETDP1HSD17B10TSHRCYP3A4 | |
| SCHEMBL28479770 | 0.75 | ALDH1A1 (0.40) | KDM4ETDP1TSHRCYP3A4MAPT | |
| SCHEMBL9676449 | 0.69 | TDP1 (0.50) | KDM4ETDP1HSD17B10TSHRCYP3A4 | |
| SCHEMBL5313843 | 0.68 | KDM4E (0.42) | KDM4ETDP1HSD17B10ERN1TSHR | |
| SCHEMBL722679 | 0.68 | KDM4E (0.55) | KDM4ETDP1HSD17B10TSHRCYP3A4 | |
| SCHEMBL1636077 | 0.67 | TDP1 (0.60) | KDM4ETDP1HSD17B10TSHRCYP3A4 | |
| SCHEMBL19420578 | 0.67 | GPR35 (0.61) | KDM4ETDP1HSD17B10TSHRCYP3A4 | |
| SCHEMBL1200250 | 0.67 | KDM4E (0.53) | KDM4ETDP1HSD17B10TSHRCYP3A4 | |
| SCHEMBL9451720 | 0.67 | KDM4E (0.41) | KDM4ETDP1HSD17B10TSHRMAPT | |
| SCHEMBL2388710 | 0.67 | TSHR (0.50) | KDM4ETDP1TSHRGPR35L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109311846-A | Novel 6-membered Heteroaromatic Substituted Cyanoindole Derivatives as NIK Inhibitors | 杨森制药有限公司 | 2019-02-05 | — | — | CN | disclosed |