SCHEMBL28869669

SCHEMBL28869669

O=C(NO)c1cc(F)ccc1Cl

nearest known ligand 0.47

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
HDAC8 Q9BY41 1/20 0.47
HDAC1 Q13547 2/20 0.47
HDAC6 Q9UBN7 2/20 0.47
HPGD P15428 2/20 0.46
ALDH1A1 P00352 1/20 0.46
ANO1 Q5XXA6 1/20 0.45
CES2 O00748 2/20 0.44
CES1 P23141 2/20 0.44
FADS1 O60427 1/20 0.41
PPARG P37231 1/20 0.41
HDAC3 O15379 1/20 0.41
HDAC2 Q92769 1/20 0.41
KEAP1 Q14145 1/20 0.40
NPC1 O15118 1/20 0.40
RAB9A P51151 1/20 0.40
CSF1R P07333 1/20 0.39
CLCN2 P51788 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15471930 0.83 ALDH1A1 (0.68) HPGDALDH1A1ANO1CES2CES1
SCHEMBL7985019 0.83 SMN1; SMN2 (0.54) HPGDALDH1A1ANO1CES2CES1
SCHEMBL27676473 0.80 ALDH1A1 (0.46) HPGDALDH1A1ANO1CES2CES1
Methylamine SCHEMBL7258774 0.80 SMN1; SMN2 (0.51) HPGDALDH1A1ANO1CES2CES1
SCHEMBL23430714 0.79 HSD17B10 (0.49) HPGDALDH1A1ANO1PPARGNPC1
SCHEMBL18896189 0.79 KCNA3 (0.47) HPGDALDH1A1ANO1
SCHEMBL30690131 0.78 P2RX1 (0.55) HDAC1HDAC6ALDH1A1CES2CES1
SCHEMBL6308964 0.78 P2RX1 (0.55) HDAC1HDAC6ALDH1A1CES2CES1
SCHEMBL786240 0.78 ALDH1A1 (0.63) ALDH1A1ANO1CES2CES1KEAP1
SCHEMBL477556 0.78 CES2 (0.48) HPGDALDH1A1ANO1CES2CES1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115093377-B Haloalkyl-containing 1,2, 4-oxadiazole derivative and preparation method and application thereof 贵州大学 2023-04-07 CN disclosed
CN-115093377-A Haloalkyl-containing 1,2, 4-oxadiazole derivative and preparation method and application thereof 贵州大学 2022-09-23 CN disclosed