Sugi Predict

Sugi Predict / Compounds / SCHEMBL786240

SCHEMBL786240

SCHEMBL786240

O=C(O)c1cc(F)ccc1Cl

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 2/20 0.63
▸ TP53 P04637 1/20 0.63
▸ KEAP1 Q14145 1/20 0.59
▸ TDP1 Q9NUW8 3/20 0.53
▸ KDM4E B2RXH2 2/20 0.53
▸ POLB P06746 2/20 0.53
▸ NPC1 O15118 1/20 0.53
▸ MAPT P10636 1/20 0.53
▸ RAB9A P51151 1/20 0.53
▸ LMNA P02545 1/20 0.52
▸ CLCN2 P51788 1/20 0.49
▸ CTSB P07858 1/20 0.49
▸ CES2 O00748 2/20 0.48
▸ CES1 P23141 2/20 0.48
▸ FABP3 P05413 1/20 0.48
▸ FABP4 P15090 1/20 0.48
▸ TSHR P16473 3/20 0.47
▸ CASP1 P29466 1/20 0.47
▸ SMN1; SMN2 Q16637 1/20 0.47
▸ GRIK1 P39086 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3128937 0.84 GRIK1 (0.55) ALDH1A1TP53TDP1KDM4EPOLB
SCHEMBL477556 0.83 CES2 (0.48) ALDH1A1TP53KEAP1CLCN2CES2
SCHEMBL195310 0.83 TSHR (0.63) ALDH1A1TP53KEAP1NPC1RAB9A
SCHEMBL22148384 0.81 TTR (0.70) ALDH1A1TP53KDM4ELMNAGRIK1
SCHEMBL1785686 0.81 ALDH1A1 (0.50) ALDH1A1TP53KEAP1MAPTLMNA
SCHEMBL5884181 0.81 CES2 (0.47) ALDH1A1TP53KEAP1POLBLMNA
SCHEMBL30954398 0.81 CES2 (0.47) ALDH1A1TP53KEAP1POLBRAB9A
SCHEMBL14783994 0.80 DCLRE1B (0.57) ALDH1A1TP53FABP3FABP4GRIK1
SCHEMBL336978 0.79 KEAP1 (0.65) ALDH1A1KEAP1TDP1KDM4EPOLB
SCHEMBL30520290 0.79 KEAP1 (0.65) ALDH1A1KEAP1TDP1KDM4EPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 231 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3551633-B1 SUBSTITUTED PYRAZOLOAZEPIN-4-ONES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS LEO PHARMA AS (DK) 2021-03-31 — — EP claimed
EP-3551633-A1 SUBSTITUTED PYRAZOLOAZEPIN-4-ONES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS Leo Pharma A/S (DK) 2019-10-16 — — EP claimed
EP-3551634-A1 SUBSTITUTED PYRAZOLOAZEPIN-8-ONES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS Leo Pharma A/S (DK) 2019-10-16 — — EP claimed
WO-2018108231-A1 SUBSTITUTED PYRAZOLOAZEPIN-8-ONES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS LEO PHARMA A/S (DK) 2018-06-21 — — WO claimed
WO-2018108230-A1 SUBSTITUTED PYRAZOLOAZEPIN-4-ONES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS LEO PHARMA A/S (DK) 2018-06-21 — — WO claimed
CN-100556889-C N-replaces-2,4-two chloro-5-fluorobenzamides and preparation thereof and application UNIV ZHEJIANG TECHNOLOGY (CN) 2009-11-04 — — CN claimed
CN-101033198-A Compound of N-substituted-2,4-dichloro-5-fluorobenzamide, preparation and application thereof UNIV ZHEJIANG TECHNOLOGY (CN) 2007-09-12 — — CN claimed
CN-1091418-A A kind of preparation 2, the method for 4-two chloro-5-fluorobenzoic acids FUXIN CITY CHEMICAL INST (CN) 1994-08-31 — — CN claimed
CN-1007150-B SYNTHESIS OF 2,4-DICHLOR-5-FLUOR BENZOIC ACID TIANJIN PHARMACEUTIC INDUSTRY (CN) 1990-03-14 — — CN claimed
CN-1006888-B PROCESS FOR PREPARING 2, 4-DICHLORO-5-FLUORO-BENZOIC ACID BAYER AG (DE) 1990-02-21 — — CN claimed
CN-1031074-A 2,4-two chloro-5-fluorobenzoic acids synthetic TIANJIN RESEARCH INST OF MEDIC (CN) 1989-02-15 — — CN claimed
CN-85107015-A Preparation 2, the benzoic method of 4-two chloro-5-fluoro- — 1987-04-01 — — CN claimed
US-20260049060-A1 TETRAHYDROISOQUINOLINYLMETHYLBENZAMIDE COMPOUNDS NATIONAL HEALTH RES INST (TW) 2026-02-19 — — US disclosed
US-12545651-B2 Diphenylamine-linked chiral bis(oxazoline) ligand without C2-symmetry, synthesis method and application thereof ZHEJIANG UNIVERSITY OF TECHNOLOGY (CN) 2026-02-10 — — US disclosed
US-20250214974-A1 INHIBITING MONOACYLGLYCEROL LIPASE (MAGL) PSY THERAPEUTICS, INC. (US) 2025-07-03 — — US disclosed
CN-120152713-A Tricyclic aryl derivatives and compositions and methods thereof 昂胜医疗科技公司 2025-06-13 — — CN disclosed
CN-87100354-A Derivatives of 7- (azabicycloalkyl) -quinolone-and 7- (azabicycloalkyl) -naphthyridonecarboxylic acids — 1987-09-02 — — CN disclosed
CN-85107015-A Preparation 2, the benzoic method of 4-two chloro-5-fluoro- — 1987-04-01 — — CN disclosed
US-4500740-A Hydrolysis of water-insoluble organic halides UOP INC. (US) 1985-02-19 — — US disclosed
US-3953595-A Substituted benzoic acid hypolipemic agents PFIZER INC. (US) 1976-04-27 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260049060-A1 TETRAHYDROISOQUINOLINYLMETHYLBENZAMIDE COMPOUNDS OPRK1, OPRD1, OPRM1 ALDH1A1 1415/4885TP53 4541/4885KEAP1 530/4885
US-20250214974-A1 INHIBITING MONOACYLGLYCEROL LIPASE (MAGL) MGLL, PNLIP, LIPC ALDH1A1 1923/4885TP53 4322/4885KEAP1 1092/4885
US-12545651-B2 Diphenylamine-linked chiral bis(oxazoline) ligand without C2-symmetry, synthesis method and application thereof AOC2, AOC1, AOC3 ALDH1A1 318/4885TP53 4072/4885KEAP1 431/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.