Spermine

Spermine

SCHEMBL288720

NCCCNCCCCNCCCN.NCCCNCCCCNCCCN

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 5/20 1.00
CA6 P23280 5/20 1.00
CA7 P43166 5/20 1.00
CA9 Q16790 5/20 1.00
CA14 Q9ULX7 5/20 1.00
CA5B Q9Y2D0 5/20 1.00
CA2 P00918 4/20 1.00
CA4 P22748 4/20 1.00
CA5A P35218 4/20 1.00
ALOX15 P16050 3/20 1.00
F13A1 P00488 2/20 1.00
CYP1A2 P05177 2/20 1.00
THPO P40225 2/20 1.00
CASP2 P42575 2/20 1.00
MEN1 O00255 2/20 1.00
RECQL P46063 2/20 1.00
KMT2A Q03164 2/20 1.00
CYP2C19 P33261 1/20 1.00
HSD17B10 Q99714 1/20 1.00
CA3 P07451 3/20 0.93

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Spermine SCHEMBL30446193 1.00 CA12 (1.00) CA12CA6CA7CA9CA14
Spermine SCHEMBL8514287 1.00 CA12 (1.00) CA12CA6CA7CA9CA14
Spermine SCHEMBL14965 1.00 CA12 (1.00) CA12CA6CA7CA9CA14
SCHEMBL12002491 0.96 CA12 (0.93) CA12CA6CA7CA9CA14
Spermine SCHEMBL431884 0.96 CA12 (1.00) CA12CA6CA7CA9CA14
Spermine SCHEMBL1167355 0.96 UBE2N (1.00) CA12CA6CA7CA9CA14
Spermine SCHEMBL6328887 0.96 CA12 (0.93) CA12CA6CA7CA9CA14
Spermine SCHEMBL1273895 0.96 CA12 (0.93) CA12CA6CA7CA9CA14
SCHEMBL3159000 0.96 CA12 (0.93) CA12CA6CA7CA9CA14
SCHEMBL995526 0.96 CA12 (0.93) CA12CA6CA7CA9CA14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106635953-B Serum-free and protein-free cell culture medium 昆明润什生物科技有限公司 2021-02-19 CN claimed
EP-2647656-A2 Bioresorbable and biocompatible thermoplastic elastomer having a shape memory, particularly for biomedical applications and a process for their preparation Centrum Materialów Polimerowych i Weglowych PAN (PL) 2013-10-09 EP claimed
WO-2018134329-A1 METABOLIC BIOMARKER SET FOR ASSESSING OVARIAN CANCER BIOCRATES LIFE SCIENCES AG (AT) 2018-07-26 WO disclosed
CN-105168046-B A kind of hair growth composition containing plant extracts 珀莱雅化妆品股份有限公司 2018-01-30 CN disclosed
EP-3193852-A1 NMDA RECEPTOR ANTAGONISTS FOR TREATING GAUCHER DISEASE Yeda Research and Development Co., Ltd. (IL) 2017-07-26 EP disclosed
EP-3191845-A1 BIOMARKERS FOR ASSESSING BREAST CANCER IDCGS Clínica de Diagnósticos Médicos Ltda (BR) 2017-07-19 EP disclosed
EP-3126841-A1 BIOMARKERS FOR ASSESSING HIV IDCGS clinica de Diagnosticos Medicos (BR) 2017-02-08 EP disclosed
EP-2427773-B1 METHOD OF DIAGNOSING ASPHYXIA INFANDX AG (DE) 2016-07-06 EP disclosed
WO-2016038616-A1 NMDA RECEPTOR ANTAGONISTS FOR TREATING GAUCHER DISEASE YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) 2016-03-17 WO disclosed
WO-2016038157-A1 BIOMARKERS FOR ASSESSING BREAST CANCER IDCGS CLÍNICA DE DIAGNÓSTICOS MÉDICOS LTDA (BR) 2016-03-17 WO disclosed
CN-105168046-A Hair growth promoting composition containing plant extracts PROYA COSMETICS CO LTD 2015-12-23 CN disclosed
WO-2011012553-A1 METHOD FOR PREDICTING THE LIKELIHOOD OF AN ONSET OF AN INFLAMMATION ASSOCIATED ORGAN FAILURE BIOCRATES LIFE SCIENCES AG (AT) 2011-02-03 WO disclosed
WO-2010128054-A1 METHOD OF DIAGNOSING ASPHYXIA BIOCRATES LIFE SCIENCES AG (AT) 2010-11-11 WO disclosed
US-20100063322-A1 NOVEL POLYAMINE DERIVATIVES NIHON UNIVERSITY (JP) 2010-03-11 US disclosed
EP-2096106-A1 NOVEL POLYAMINE DERIVATIVES Nihon University (JP) 2009-09-02 EP disclosed
WO-2008147214-A1 FOOD ARTICLE WITH IMPROVED SHELF LIFE NOFIMA AKVAFORSK-FISKERIFORSKNING AS (NO) 2008-12-04 WO disclosed
US-20070129505-A1 Bioabsorbable compounds and compositions containing them TYCO HEALTHCARE GROUP LP 2007-06-07 US disclosed
CN-1349402-A Encapsulation of bioactive complexes in liposomes LIPOSOME CO INC (US) 2002-05-15 CN disclosed
US-4373026-A FERMENTATION OF PENICILLIUM AMANO PHARMACEUTICAL CO., LTD. (JP) 1983-02-08 US disclosed
US-4371621-A OXIDATION OF SPERMINE AND SPERMIDINE AMANO PHARMACEUTICAL CO., LTD. (JP) 1983-02-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100063322-A1 NOVEL POLYAMINE DERIVATIVES SRM, SMS, H1-3 CA12 2932/4885CA6 2977/4885CA7 2247/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.