Sugi Predict

Sugi Predict / Compounds / SCHEMBL2887464

SCHEMBL2887464

SCHEMBL2887464

COC(=O)c1c(C(O)c2cc3ccccc3o2)n(S(=O)(=O)c2ccccc2)c2cccc(OCc3ccccc3)c12

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ EDNRA P25101 1/20 0.39
▸ ABCG2 Q9UNQ0 3/20 0.37
▸ BCL2 P10415 1/20 0.37
▸ BID P55957 1/20 0.37
▸ MCL1 Q07820 1/20 0.37
▸ ABCB1 P08183 2/20 0.36
▸ MMP2 P08253 1/20 0.36
▸ MTNR1B P49286 1/20 0.36
▸ BCHE P06276 1/20 0.35
▸ ACHE P22303 1/20 0.35
▸ HTR6 P50406 1/20 0.35
▸ PTGER1 P34995 1/20 0.34
▸ PLA2G10 O15496 1/20 0.34
▸ BCAT1 P54687 1/20 0.34
▸ RECQL P46063 1/20 0.34
▸ GAA P10253 3/20 0.34
▸ MEN1 O00255 2/20 0.34
▸ KMT2A Q03164 2/20 0.34
▸ LMNA P02545 2/20 0.34
▸ KDM4E B2RXH2 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12344893 0.94 EDNRA (0.38) EDNRAABCG2BCL2BIDMCL1
SCHEMBL2887785 0.85 MAOA (0.41) BCL2BIDMCL1HTR6GAA
SCHEMBL2885109 0.85 EDNRA (0.41) EDNRAABCG2BCL2BIDMCL1
SCHEMBL2887943 0.83 MEN1 (0.42) MTNR1BHTR6BCAT1RECQLMEN1
SCHEMBL12344899 0.81 SRC (0.46) MTNR1BBCAT1RECQLGAAMEN1
SCHEMBL2887197 0.79 HTR6 (0.41) HTR6BCAT1GAAMEN1KMT2A
SCHEMBL2885831 0.78 MAPT (0.35) EDNRAGAAMEN1KMT2ALMNA
SCHEMBL12344889 0.75 KDM4E (0.38) MMP2BCAT1GAAMEN1KMT2A
SCHEMBL12344897 0.72 EDNRA (0.40) EDNRAABCG2BCL2BIDMCL1
SCHEMBL2886004 0.70 CASP3 (0.43) BCL2BIDMCL1HTR6BCAT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2035429-B1 FUSED [d]PYRIDAZIN-7-ONES CEPHALON INC (US) 2012-09-19 — — EP disclosed
US-7732447-B2 such as 4-Pyridin-3-yl-2,5-dihydro-pyridazino[4,5-b]indol-1-one, used as inhibitors of vascular endothelial growth factor receptor (VEGFR) kinase, mixed lineage kinase (MLK) or cyclin-dependent kinase (CDK); treatment of angiogenic disorders and neurodegenerative diseases CEPHALON, INC. (US) 2010-06-08 — — US disclosed
US-7732447-B2 such as 4-Pyridin-3-yl-2,5-dihydro-pyridazino[4,5-b]indol-1-one, used as inhibitors of vascular endothelial growth factor receptor (VEGFR) kinase, mixed lineage kinase (MLK) or cyclin-dependent kinase (CDK); treatment of angiogenic disorders and neurodegenerative diseases CEPHALON, INC. (US) 2010-06-08 — — US disclosed
EP-2035429-A1 FUSED [d]PYRIDAZIN-7-ONES Cephalon, Inc. (US) 2009-03-18 — — EP disclosed
US-20070299061-A1 Fused [d]pyridazin-7-ones CEPHALON, INC. (US) 2007-12-27 — — US disclosed
US-20070299061-A1 Fused [d]pyridazin-7-ones CEPHALON, INC. (US) 2007-12-27 — — US disclosed
WO-2007149557-A1 FUSED [d]PYRIDAZIN-7-ONES CEPHALON, INC. (US) 2007-12-27 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070299061-A1 Fused [d]pyridazin-7-ones CDK5, CDK5R1, CDK7 EDNRA 2154/4885ABCG2 3180/4885BCL2 1754/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.