Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 1/20 | 0.46 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.44 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.41 |
| ▸ | CPT1A | P50416 | 1/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | JMJD6 | Q6NYC1 | 4/20 | 0.39 |
| ▸ | CCNC | P24863 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.35 |
| ▸ | SCD | O00767 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20187358 | 1.00 | ADAM17 (0.46) | ADAM17KCNK3HCRTR2CPT1ARIPK1 | |
| SCHEMBL20202191 | 0.82 | ALDH1A1 (0.46) | ADAM17HCRTR2MGLL | |
| SCHEMBL165326 | 0.80 | JMJD6 (0.47) | ADAM17KCNK3JMJD6 | |
| SCHEMBL26238310 | 0.78 | CHRNB2 (0.49) | CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4 | |
| SCHEMBL175142 | 0.75 | JMJD6 (0.50) | ADAM17KCNK3JMJD6 | |
| SCHEMBL15813622 | 0.74 | RIPK1 (0.36) | HCRTR2CPT1ARIPK1CCNCCDK8 | |
| SCHEMBL17574589 | 0.73 | KCNK3 (0.70) | KCNK3 | |
| SCHEMBL8206746 | 0.73 | ADAM17 (0.39) | ADAM17KCNK3MGLLDDB1CRBN | |
| SCHEMBL20187340 | 0.72 | KMT2A (0.38) | RIPK1MGLLCCNCCDK8 | |
| SCHEMBL28887425 | 0.72 | KMT2A (0.43) | RIPK1CCNCCDK8KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110234638-A | Heteroaryl phenoxy benzamide KAPPA opiates ligand | 辉瑞大药厂 | 2019-09-13 | — | — | CN | disclosed |