SCHEMBL28876491

SCHEMBL28876491

CC(=O)c1nc(OC(N)=O)ccc1Br

nearest known ligand 0.33

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
NNMT P40261 3/20 0.33
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32
IKBKB O14920 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21046517 0.81 POLB (0.43) NNMTMEN1KMT2A
SCHEMBL25285040 0.80 NNMT (0.35) NNMTMEN1KMT2AIKBKB
SCHEMBL28931441 0.79 NNMT (0.45) NNMTMEN1KMT2A
SCHEMBL28876701 0.79 MEN1 (0.35) NNMTMEN1KMT2A
SCHEMBL21550811 0.76 MEN1 (0.33) NNMTMEN1KMT2A
SCHEMBL28737030 0.73 NNMT (0.33) NNMTMEN1KMT2A
SCHEMBL28876586 0.73 NNMT (0.33) NNMTMEN1KMT2A
SCHEMBL3341732 0.72 NNMT (0.53) NNMTIKBKB
SCHEMBL29150549 0.72 PARP1 (0.31)
SCHEMBL28876653 0.71 ALOX5 (0.32)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114945366-A HPK1 antagonists and uses thereof 林伯士萨顿公司 2022-08-26 CN disclosed