Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Trifluoroacetamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 3/20 | 0.32 |
| ▸ | OR51E2 | Q9H255 | 2/20 | 0.32 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.32 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.31 |
| ▸ | ODC1 | P11926 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.30 |
| ▸ | BLM | P54132 | 2/20 | 0.30 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.30 |
| ▸ | GABRP | O00591 | 1/20 | 0.30 |
| ▸ | GABRD | O14764 | 1/20 | 0.30 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetamide SCHEMBL20137335 | 1.00 | HDAC6 (0.35) | HDAC6ALDH1A1POLBSMN1; SMN2CA2 | |
| Trifluoroacetamide SCHEMBL4577328 | 0.88 | ALDH1A1 (0.47) | HDAC6ALDH1A1TSHR | |
| Trifluoroacetamide SCHEMBL28877283 | 0.88 | NFKB1 (0.43) | HDAC6ALDH1A1CA2LMNAODC1 | |
| Trifluoroacetamide SCHEMBL142 | 0.86 | — | — | |
| Trifluoroacetamide SCHEMBL27678123 | 0.86 | LMNA (0.42) | ALDH1A1POLBSMN1; SMN2CA2OR51E2 | |
| Trifluoroacetamide SCHEMBL10618561 | 0.85 | LMNA (0.46) | HDAC6ALDH1A1CA2LMNAKMT2A | |
| Trifluoroacetamide SCHEMBL28877268 | 0.85 | LMNA (0.46) | HDAC6ALDH1A1CA2LMNAKMT2A | |
| Trifluoroacetamide SCHEMBL6982843 | 0.82 | — | — | |
| Trifluoroacetamide SCHEMBL3655478 | 0.82 | — | — | |
| Trifluoroacetamide SCHEMBL11793075 | 0.82 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115260261-A | Preparation method of deoxynucleoside solid-phase carrier modified by fluorescent dye | 苏州诺维康生物科技有限公司 | 2022-11-01 | — | — | CN | claimed |
| CN-115260261-A | Preparation method of deoxynucleoside solid-phase carrier modified by fluorescent dye | 苏州诺维康生物科技有限公司 | 2022-11-01 | — | — | CN | disclosed |