Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Trifluoroacetamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetamide SCHEMBL28877296 | 0.88 | HDAC6 (0.35) | ALDH1A1TSHRHDAC6 | |
| Trifluoroacetamide SCHEMBL16106178 | 0.88 | TSHR (0.33) | ALDH1A1TSHR | |
| Trifluoroacetamide SCHEMBL20137335 | 0.88 | HDAC6 (0.35) | ALDH1A1TSHRHDAC6 | |
| Trifluoroacetic Acid SCHEMBL1833664 | 0.82 | TSHR (0.47) | ALDH1A1TSHRHDAC6 | |
| Trifluoroacetamide SCHEMBL28877283 | 0.82 | NFKB1 (0.43) | ALDH1A1TSHRHDAC6 | |
| Trifluoroacetamide SCHEMBL27678123 | 0.80 | LMNA (0.42) | ALDH1A1TSHR | |
| Trifluoroacetamide SCHEMBL142 | 0.80 | — | — | |
| Trifluoroacetamide SCHEMBL10618561 | 0.80 | LMNA (0.46) | ALDH1A1TSHRHDAC6 | |
| Trifluoroacetamide SCHEMBL28877268 | 0.80 | LMNA (0.46) | ALDH1A1TSHRHDAC6 | |
| Trifluoroacetamide SCHEMBL27887692 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7462451-B2 | Compositions for modifying nucleic acids | THIRD WAVE TECHNOLOGIES, INC. (US) | 2008-12-09 | — | — | US | disclosed |
| US-20050277138-A1 | Reactive functional groups | THIRD WAVE TECHNOLOGIES, INC. (US) | 2005-12-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050277138-A1 | Reactive functional groups | RNGTT, POLRMT, NSUN2 | ALDH1A1 2481/4885TSHR 3349/4885HDAC6 1826/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.