Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Silver. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.65 |
| ▸ | CA9 | Q16790 | 4/20 | 0.54 |
| ▸ | CA12 | O43570 | 3/20 | 0.54 |
| ▸ | CA1 | P00915 | 3/20 | 0.54 |
| ▸ | CA2 | P00918 | 3/20 | 0.54 |
| ▸ | CA4 | P22748 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 5/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MPO | P05164 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | CA6 | P23280 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9065915 | 0.79 | ALDH1A1 (1.00) | ALDH1A1CA9CA12CA1CA2 | |
| 4-Nitroaniline SCHEMBL16451 | 0.79 | ALDH1A1 (1.00) | ALDH1A1CA9CA12CA1CA2 | |
| 4-Nitroaniline SCHEMBL13529022 | 0.79 | ALDH1A1 (1.00) | ALDH1A1CA9CA12CA1CA2 | |
| 4-Nitroaniline SCHEMBL27963818 | 0.79 | ALDH1A1 (1.00) | ALDH1A1CA9CA12CA1CA2 | |
| 4-Nitroaniline SCHEMBL6956705 | 0.77 | ALDH1A1 (0.95) | ALDH1A1CA9CA12CA1CA2 | |
| 4-Nitroaniline SCHEMBL702809 | 0.77 | ALDH1A1 (0.95) | ALDH1A1CA9CA12CA1CA2 | |
| 4-Nitroaniline SCHEMBL356765 | 0.77 | ALDH1A1 (0.95) | ALDH1A1CA9CA12CA1CA2 | |
| 4-Nitroaniline SCHEMBL7158084 | 0.77 | ALDH1A1 (0.95) | ALDH1A1CA9CA12CA1CA2 | |
| 4-Nitroaniline SCHEMBL7158091 | 0.77 | ALDH1A1 (0.95) | ALDH1A1CA9CA12CA1CA2 | |
| 4-Nitroaniline SCHEMBL21825602 | 0.77 | ALDH1A1 (0.95) | ALDH1A1CA9CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110480027-B | Method for preparing two-dimensional ultrathin silicon wafer loaded with silver nanoparticles | 盐城工学院 | 2021-04-13 | — | — | CN | disclosed |
| CN-110480027-A | A method of preparing two-dimensional ultrathin silicon wafer silver nanoparticles loaded | YANCHENG INST TECH | 2019-11-22 | — | — | CN | disclosed |