Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | METAP2 | P50579 | 1/20 | 0.47 |
| ▸ | METAP1 | P53582 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 8-Aminoquinoline SCHEMBL19748791 | 0.93 | PARP1 (0.57) | PARP1LMNAKDRMETAP2METAP1 | |
| Quinoline SCHEMBL14720516 | 0.87 | ALDH1A1 (0.61) | PARP1KDRALDH1A1HDAC1HDAC2 | |
| 8-Aminoquinoline SCHEMBL28078884 | 0.85 | ALDH1A1 (0.63) | PARP1LMNAMETAP2METAP1ALDH1A1 | |
| 8-Aminoquinoline SCHEMBL28695606 | 0.81 | L3MBTL1 (0.56) | PARP1LMNAKDRALDH1A1HDAC1 | |
| 8-Aminoquinoline SCHEMBL28223663 | 0.81 | PARP1 (0.53) | PARP1LMNAALDH1A1HDAC1TDP1 | |
| 8-Aminoquinoline SCHEMBL28692373 | 0.81 | KMT2A (0.56) | PARP1LMNAMETAP2METAP1HDAC6 | |
| Quinoline SCHEMBL5272119 | 0.79 | ALDH1A1 (0.74) | PARP1ALDH1A1HDAC1HDAC2CYP3A4 | |
| Quinoline SCHEMBL2201840 | 0.79 | ALDH1A1 (0.74) | PARP1ALDH1A1HDAC1HDAC2CYP3A4 | |
| Quinoline SCHEMBL28083721 | 0.79 | PARP1 (0.81) | PARP1LMNAKDRALDH1A1MAPT | |
| 8-Aminoquinoline SCHEMBL28214879 | 0.78 | PARP1 (0.59) | PARP1LMNAMETAP2METAP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110437148-A | A kind of fluorination process of 8- amide groups quinoline | HARBIN INST TECHNOLOGY SHENZHEN | 2019-11-12 | — | — | CN | disclosed |