Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SOS1 | Q07889 | 4/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28880344 | 1.00 | L3MBTL1 (0.35) | L3MBTL1SMN1; SMN2MAPK1ALDH1A1LMNA | |
| SCHEMBL514813 | 0.86 | L3MBTL1 (0.41) | L3MBTL1SMN1; SMN2MAPK1ALDH1A1LMNA | |
| SCHEMBL28880523 | 0.83 | SOS1 (0.35) | L3MBTL1SMN1; SMN2MAPK1ALDH1A1LMNA | |
| SCHEMBL28880525 | 0.83 | SOS1 (0.35) | L3MBTL1SMN1; SMN2MAPK1ALDH1A1LMNA | |
| SCHEMBL28880407 | 0.80 | SMN1; SMN2 (0.39) | L3MBTL1SMN1; SMN2MAPK1ALDH1A1LMNA | |
| SCHEMBL30292599 | 0.80 | SMN1; SMN2 (0.39) | L3MBTL1SMN1; SMN2MAPK1ALDH1A1LMNA | |
| SCHEMBL28880354 | 0.77 | SOS1 (0.34) | ALDH1A1LMNASOS1 | |
| SCHEMBL28880355 | 0.77 | SOS1 (0.34) | ALDH1A1LMNASOS1 | |
| SCHEMBL28880383 | 0.77 | HTT (0.35) | ALDH1A1LMNA | |
| SCHEMBL28880382 | 0.77 | HTT (0.35) | ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117940411-A | Quinazoline derivative, or preparation method and application thereof | 浙江海正药业股份有限公司 | 2024-04-26 | — | — | CN | disclosed |
| CN-116546985-A | Pyridopyrimidine derivative and preparation method and application thereof | 浙江海正药业股份有限公司 | 2023-08-04 | — | — | CN | disclosed |
| CN-115135315-A | SOS1 inhibitors | 米拉蒂治疗股份有限公司 | 2022-09-30 | — | — | CN | disclosed |