Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B known ✓ | P49841 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.52 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | CES2 | O00748 | 1/20 | 0.48 |
| ▸ | CES1 | P23141 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | PKM | P14618 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | PTPRA | P18433 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL27415902 | 0.91 | ALDH1A1 (0.52) | LMNAP4HTMNAPRTL3MBTL1CES2 | |
| SCHEMBL363240 | 0.87 | — | — | |
| SCHEMBL11731719 | 0.85 | — | — | |
| Formic Acid SCHEMBL27440282 | 0.84 | CES2 (0.41) | LMNAP4HTMNAPRTL3MBTL1CES2 | |
| Phosphoric Acid SCHEMBL28997991 | 0.84 | FDPS (0.44) | LMNAP4HTMNAPRTL3MBTL1CES2 | |
| Boric Acid SCHEMBL27872370 | 0.83 | KDM4E (0.42) | LMNAP4HTMNAPRTL3MBTL1CES2 | |
| Dipyridyl SCHEMBL30976994 | 0.75 | KDM4E (0.74) | LMNAP4HTMNAPRTL3MBTL1CES2 | |
| Dipyridyl SCHEMBL18601618 | 0.75 | KDM4E (0.74) | LMNAP4HTMNAPRTL3MBTL1CES2 | |
| Dipyridyl SCHEMBL2792069 | 0.75 | KDM4E (0.74) | LMNAP4HTMNAPRTL3MBTL1CES2 | |
| Dipyridyl SCHEMBL7773433 | 0.75 | KDM4E (0.74) | LMNAP4HTMNAPRTL3MBTL1CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110339368-B | Preparation method of reduction-responsive targeting polyethylene glycol-polycarbonate maytansine prodrug micelle | 苏州大学 | 2022-08-16 | — | — | CN | claimed |
| CN-108909088-B | Aluminum alloy based on magnetron sputtering diamond-like carbon film and application thereof | 苏州大学 | 2020-05-05 | — | — | CN | claimed |
| CN-108705827-B | Metal section bar with magnetron sputtering diamond-like carbon film and application | 苏州大学 | 2020-01-14 | — | — | CN | claimed |
| CN-110339368-B | Preparation method of reduction-responsive targeting polyethylene glycol-polycarbonate maytansine prodrug micelle | 苏州大学 | 2022-08-16 | — | — | CN | disclosed |
| CN-108909088-B | Aluminum alloy based on magnetron sputtering diamond-like carbon film and application thereof | 苏州大学 | 2020-05-05 | — | — | CN | disclosed |
| CN-108705827-B | Metal section bar with magnetron sputtering diamond-like carbon film and application | 苏州大学 | 2020-01-14 | — | — | CN | disclosed |