Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CETP | P11597 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2888190 | 1.00 | CETP (0.33) | CETP | |
| Hydrochloric Acid SCHEMBL3524168 | 0.97 | CETP (0.32) | CETP | |
| SCHEMBL8954577 | 0.74 | CETP (0.38) | CETP | |
| SCHEMBL4807351 | 0.72 | TSHR (0.33) | CETP | |
| SCHEMBL4807354 | 0.72 | TSHR (0.33) | CETP | |
| SCHEMBL3883303 | 0.72 | TSHR (0.33) | CETP | |
| SCHEMBL13395753 | 0.72 | TSHR (0.33) | CETP | |
| SCHEMBL13431489 | 0.71 | — | — | |
| Hydrochloric Acid SCHEMBL3171229 | 0.70 | TSHR (0.32) | CETP | |
| SCHEMBL8886206 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7838550-B2 | Selective N-sulfonylation of 2-amino fluoro- and trifluoroalkyl substituted alcohols | WYETH LLC (US) | 2010-11-23 | — | — | US | claimed |
| EP-1984347-A1 | SELECTIVE N-SULFONYLATION OF 2-AMINO TRIFLUOROALKYL SUBSTITUTED ALCOHOLS | Wyeth a Corporation of the State of Delaware (US) | 2008-10-29 | — | — | EP | claimed |
| WO-2007098030-A1 | SELECTIVE N-SULFONYLATION OF 2-AMINO TRIFLUOROALKYL SUBSTITUTED ALCOHOLS | WYETH (US) | 2007-08-30 | — | — | WO | claimed |
| US-20070197800-A1 | Selective n-sulfonylation of 2-amino flouro-and trifluoroalkyl substituted alcohols | WYETH (US) | 2007-08-23 | — | — | US | claimed |
| US-7858658-B2 | Fluoro- and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof | WYETH LLC (US) | 2010-12-28 | — | — | US | disclosed |
| US-7838550-B2 | Selective N-sulfonylation of 2-amino fluoro- and trifluoroalkyl substituted alcohols | WYETH LLC (US) | 2010-11-23 | — | — | US | disclosed |
| US-7838550-B2 | Selective N-sulfonylation of 2-amino fluoro- and trifluoroalkyl substituted alcohols | WYETH LLC (US) | 2010-11-23 | — | — | US | disclosed |
| US-7838550-B2 | Selective N-sulfonylation of 2-amino fluoro- and trifluoroalkyl substituted alcohols | WYETH LLC (US) | 2010-11-23 | — | — | US | disclosed |
| US-7687666-B2 | Methods for preparing sulfonamide substituted alcohols and intermediates thereof | WYETH (US) | 2010-03-30 | — | — | US | disclosed |
| US-20090227667-A1 | FLUORO- AND TRIFLUOROALKYL-CONTAINING HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION AND DERIVATIVES THEREOF | WYETH (US) | 2009-09-10 | — | — | US | disclosed |
| US-20090221711-A1 | TRIFLUOROMETHYL-CONTAINING PHENYLSULFONAMIDE BETA AMYLOID INHIBITORS | WYETH (US) | 2009-09-03 | — | — | US | disclosed |
| US-7550629-B2 | 4-chloro-N-[(1S)-3,3,3-trifluoro-1-(hydroxymethyl)-2-(trifluoromethyl)propyl]benzenesulfonamide; 4-cyano-N-(3,3,3-trifluoro-1-hydroxymethyl-2-trifluoromethyl-propyl)-benzenesulfonamide; Alzheimer's Disease, amyloid angiopathy, systemic amyloidosis, mild cognitive impairment and Down's syndrome | WYETH (US) | 2009-06-23 | — | — | US | disclosed |
| WO-2007098030-A1 | SELECTIVE N-SULFONYLATION OF 2-AMINO TRIFLUOROALKYL SUBSTITUTED ALCOHOLS | WYETH (US) | 2007-08-30 | — | — | WO | disclosed |
| US-20070197800-A1 | Selective n-sulfonylation of 2-amino flouro-and trifluoroalkyl substituted alcohols | WYETH (US) | 2007-08-23 | — | — | US | disclosed |
| US-20070197800-A1 | Selective n-sulfonylation of 2-amino flouro-and trifluoroalkyl substituted alcohols | WYETH (US) | 2007-08-23 | — | — | US | disclosed |
| US-20070197800-A1 | Selective n-sulfonylation of 2-amino flouro-and trifluoroalkyl substituted alcohols | WYETH (US) | 2007-08-23 | — | — | US | disclosed |
| US-20070197830-A1 | Methods for preparing sulfonamide substituted alcohols and intermediates thereof | WYETH (US) | 2007-08-23 | — | — | US | disclosed |
| EP-1608638-A1 | FLUORO-AND TRIFLUOROALKYL-CONTAINING HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION AND DERIVATIVES THEREOF | Wyeth (US) | 2005-12-28 | — | — | EP | disclosed |
| WO-2004092155-A1 | FLUORO-AND TRIFLUOROALKYL-CONTAINING HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION AND DERIVATIVES THEREOF | WYETH (US) | 2004-10-28 | — | — | WO | disclosed |
| US-20040198778-A1 | Fluoro- and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof | WYETH | 2004-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221711-A1 | TRIFLUOROMETHYL-CONTAINING PHENYLSULFONAMIDE BETA AMYLOID INHIBITORS | APP, PSEN1, BACE1 | CETP 574/4885 |
| US-20090227667-A1 | FLUORO- AND TRIFLUOROALKYL-CONTAINING HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION AND DERIVATIVES THEREOF | SCN8A, CHD8, CDR2 | CETP 2921/4885 |
| US-20070197800-A1 | Selective n-sulfonylation of 2-amino flouro-and trifluoroalkyl substituted alcohols | BRAF, AFF2, SELENOI | CETP 3021/4885 |
| US-20070197830-A1 | Methods for preparing sulfonamide substituted alcohols and intermediates thereof | ADH1A, STS, ADH1C | CETP 1248/4885 |
| US-20040198778-A1 | Fluoro- and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof | BACE1, APP, PSEN1 | CETP 1163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.