Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | CDC7 | O00311 | 2/20 | 0.50 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL289907 | 0.87 | ALDH1A1 (0.59) | ALDH1A1KDM4ENPSR1NPC1CDC7 | |
| SCHEMBL290399 | 0.86 | KDM4E (0.48) | ALDH1A1KDM4ENPSR1NPC1RXFP1 | |
| SCHEMBL290306 | 0.83 | ALDH1A1 (0.59) | ALDH1A1KDM4ENPSR1NPC1CDC7 | |
| SCHEMBL289947 | 0.82 | ALDH1A1 (0.53) | ALDH1A1KDM4ENPSR1NPC1CDC7 | |
| SCHEMBL288804 | 0.82 | ALDH1A1 (0.56) | ALDH1A1KDM4ENPSR1NPC1CDC7 | |
| SCHEMBL289848 | 0.81 | KDM4E (0.55) | ALDH1A1KDM4ENPSR1NPC1CDC7 | |
| SCHEMBL290050 | 0.81 | ALDH1A1 (0.58) | ALDH1A1KDM4ENPSR1NPC1CDC7 | |
| SCHEMBL3437616 | 0.79 | MAPT (0.61) | ALDH1A1KDM4ENPSR1NPC1CDC7 | |
| SCHEMBL290278 | 0.79 | KDM4E (0.66) | ALDH1A1KDM4ENPSR1NPC1CDC7 | |
| SCHEMBL3827647 | 0.78 | KDM4E (0.69) | ALDH1A1KDM4ENPSR1NPC1CDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427447-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | Pike Pharma GmbH (CH) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010128163-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | PIKE PHARMA GMBH (CH) | 2010-11-11 | — | — | WO | disclosed |