Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.46 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.45 |
| ▸ | ALPL | P05186 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | XDH | P47989 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.43 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.43 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3435518 | 0.89 | SMN1; SMN2 (0.51) | KDM4ESMN1; SMN2RAB9AGAATARBP2 | |
| SCHEMBL288845 | 0.86 | ALDH1A1 (0.54) | KDM4ESMN1; SMN2HSD17B1HSD17B2RAB9A | |
| SCHEMBL289862 | 0.85 | APP (0.55) | KDM4ESMN1; SMN2HSD17B1HSD17B2RAB9A | |
| SCHEMBL289635 | 0.81 | KDM4E (0.57) | KDM4ESMN1; SMN2RAB9AGAATARBP2 | |
| SCHEMBL290387 | 0.80 | KDM4E (0.47) | KDM4ESMN1; SMN2RAB9AGAATARBP2 | |
| SCHEMBL289964 | 0.80 | SMN1; SMN2 (0.57) | KDM4ESMN1; SMN2HSD17B1HSD17B2RAB9A | |
| SCHEMBL3435042 | 0.79 | KDM4E (0.57) | KDM4ESMN1; SMN2RAB9AGAATARBP2 | |
| SCHEMBL14800560 | 0.78 | KDM4E (0.53) | KDM4ESMN1; SMN2RAB9AGAATARBP2 | |
| SCHEMBL19523348 | 0.77 | XDH (0.68) | KDM4ERAB9AGAATARBP2XDH | |
| SCHEMBL3436284 | 0.77 | KDM4E (0.59) | KDM4ESMN1; SMN2RAB9AGAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427447-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | Pike Pharma GmbH (CH) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010128163-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | PIKE PHARMA GMBH (CH) | 2010-11-11 | — | — | WO | disclosed |