Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | CDC7 | O00311 | 2/20 | 0.54 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | FNTA | P49354 | 1/20 | 0.46 |
| ▸ | FNTB | P49356 | 1/20 | 0.46 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10994239 | 0.90 | CDC7 (0.63) | KDM4EALDH1A1CDC7DBF4HTT | |
| SCHEMBL290306 | 0.86 | ALDH1A1 (0.59) | KDM4EALDH1A1CDC7DBF4HPGD | |
| SCHEMBL290050 | 0.84 | ALDH1A1 (0.58) | KDM4EALDH1A1CDC7DBF4HPGD | |
| SCHEMBL290675 | 0.83 | KDM4E (0.62) | KDM4EALDH1A1CDC7DBF4HPGD | |
| SCHEMBL290104 | 0.83 | KDM4E (0.59) | KDM4EALDH1A1CDC7DBF4HPGD | |
| SCHEMBL290206 | 0.82 | KDM4E (0.55) | KDM4EALDH1A1CDC7DBF4LMNA | |
| SCHEMBL290210 | 0.82 | KDM4E (0.60) | KDM4EALDH1A1CDC7DBF4HPGD | |
| SCHEMBL289746 | 0.81 | TRPM8 (0.62) | KDM4EALDH1A1CDC7DBF4HPGD | |
| SCHEMBL288845 | 0.81 | ALDH1A1 (0.54) | KDM4EALDH1A1CDC7DBF4HTT | |
| SCHEMBL289156 | 0.81 | ALDH1A1 (0.65) | KDM4EALDH1A1CDC7DBF4HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427447-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | Pike Pharma GmbH (CH) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010128163-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | PIKE PHARMA GMBH (CH) | 2010-11-11 | — | — | WO | disclosed |