Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 12/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28889218 | 0.84 | HDAC4 (0.38) | MEN1KMT2AHDAC4HDAC3HDAC7 | |
| SCHEMBL28889299 | 0.78 | HDAC4 (0.40) | MEN1KMT2AHDAC4HDAC3HDAC7 | |
| SCHEMBL28889388 | 0.78 | ALDH1A1 (0.36) | MEN1KMT2ALMNAHTTKDM4E | |
| SCHEMBL28889263 | 0.76 | HDAC4 (0.41) | HDAC4HDAC3HDAC7HDAC8HDAC6 | |
| SCHEMBL29941803 | 0.76 | HDAC4 (0.42) | MEN1KMT2AHDAC4HDAC3HDAC7 | |
| SCHEMBL28889200 | 0.75 | ADRB2 (0.41) | MEN1KMT2ALMNAHTTKDM4E | |
| SCHEMBL29893566 | 0.73 | ADRB2 (0.39) | MEN1KMT2ALMNAHTTKDM4E | |
| SCHEMBL28889291 | 0.73 | ADRB2 (0.39) | MEN1KMT2ALMNAHTTKDM4E | |
| SCHEMBL29942160 | 0.72 | HDAC4 (0.38) | MEN1KMT2AHDAC4HDAC3HDAC7 | |
| SCHEMBL29941884 | 0.71 | SMARCA2 (0.38) | LMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022222911-A1 | PYRIMIDONE COMPOUND AND USE THEREOF | 武汉人福创新药物研发中心有限公司 | 2022-10-27 | — | — | WO | disclosed |
| CN-115215862-A | Pyrimidone compounds and uses thereof | 武汉人福创新药物研发中心有限公司 | 2022-10-21 | — | — | CN | disclosed |