Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 15/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.36 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28889260 | 0.86 | SMARCA2 (0.38) | — | |
| SCHEMBL30637660 | 0.83 | HDAC4 (0.41) | HDAC4GAAHDAC3HDAC7HDAC8 | |
| SCHEMBL28959168 | 0.81 | HDAC4 (0.44) | HDAC4GAAHDAC3HDAC7HDAC8 | |
| SCHEMBL29942045 | 0.80 | HDAC4 (0.46) | HDAC4GAAHDAC3HDAC7HDAC8 | |
| SCHEMBL28889293 | 0.79 | HDAC4 (0.41) | HDAC4GAAHDAC3HDAC7HDAC8 | |
| SCHEMBL29942160 | 0.76 | HDAC4 (0.38) | HDAC4HDAC3HDAC7HDAC8HDAC6 | |
| SCHEMBL28889218 | 0.76 | HDAC4 (0.38) | HDAC4HDAC3HDAC7HDAC8HDAC6 | |
| SCHEMBL28889337 | 0.76 | MEN1 (0.39) | HDAC4HDAC3HDAC7HDAC8HDAC6 | |
| SCHEMBL28889307 | 0.73 | ADRB2 (0.38) | HDAC4HDAC3HDAC7HDAC8HDAC6 | |
| SCHEMBL28889285 | 0.73 | ALDH1A1 (0.41) | GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022222911-A1 | PYRIMIDONE COMPOUND AND USE THEREOF | 武汉人福创新药物研发中心有限公司 | 2022-10-27 | — | — | WO | disclosed |
| CN-115215862-A | Pyrimidone compounds and uses thereof | 武汉人福创新药物研发中心有限公司 | 2022-10-21 | — | — | CN | disclosed |