SCHEMBL288911

SCHEMBL288911

COc1c(Cl)ncnc1Cl

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.44
LMNA P02545 2/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
ENPP1 P22413 2/20 0.39
AURKA O14965 1/20 0.39
PDE5A O76074 1/20 0.38
ADORA3 P0DMS8 2/20 0.38
ADORA2A P29274 2/20 0.38
KMT2A Q03164 3/20 0.38
MAPT P10636 3/20 0.38
MEN1 O00255 2/20 0.38
HPGD P15428 2/20 0.36
POLB P06746 2/20 0.36
NPSR1 Q6W5P4 1/20 0.36
KDM4E B2RXH2 1/20 0.36
NPC1 O15118 1/20 0.36
RAB9A P51151 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
EGFR P00533 1/20 0.36
NFE2L2 Q16236 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9044468 0.85 ALDH1A1 (0.39) ALDH1A1LMNASMN1; SMN2ENPP1AURKA
SCHEMBL12261633 0.85 ALDH1A1 (0.39) ALDH1A1LMNASMN1; SMN2ENPP1AURKA
SCHEMBL1872205 0.84 PDE5A (0.49) ALDH1A1LMNASMN1; SMN2ENPP1AURKA
SCHEMBL28998748 0.84 ALDH1A1 (0.40) ALDH1A1LMNASMN1; SMN2ENPP1AURKA
SCHEMBL3141663 0.84 ALDH1A1 (0.38) ALDH1A1LMNASMN1; SMN2ENPP1AURKA
SCHEMBL16712808 0.84 ALDH1A1 (0.38) ALDH1A1LMNASMN1; SMN2ENPP1AURKA
SCHEMBL9046753 0.80 PGK1 (0.41) ALDH1A1LMNASMN1; SMN2AURKAPDE5A
SCHEMBL13019497 0.80 ALDH1A1 (0.36) ALDH1A1LMNASMN1; SMN2ENPP1AURKA
SCHEMBL7199405 0.79 ALDH1A1 (0.39) ALDH1A1LMNASMN1; SMN2ENPP1AURKA
SCHEMBL8419304 0.79 ENPP1 (0.45) ALDH1A1LMNASMN1; SMN2ENPP1AURKA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 566 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119591549-A Rapid synthesis method of polysubstituted pyrimidine carboxylic acid compound 南通益昊药业有限公司 2025-03-11 CN claimed
CN-119500263-A Catalyst and method for preparing 5-methoxy-4, 6-dichloropyrimidine through Kjeldahl reaction 江苏金申医药科技有限公司 2025-02-25 CN claimed
CN-118812441-A Industrial sulfanilamide production and preparation process 安达裕顺化工有限公司 2024-10-22 CN claimed
CN-116693461-A Novel synthetic method of 4, 6-dichloro-5-methoxypyrimidine 江苏中渊化学品有限公司 2023-09-05 CN claimed
CN-217423842-U High-efficient drying device is used in production of 4, 6-dichloro-5-methoxy pyrimidine 江苏金申医药科技有限公司 2022-09-13 CN claimed
CN-217221487-U Multifunctional reaction kettle for producing 4, 6-dichloro-5-methoxypyrimidine 江苏金申医药科技有限公司 2022-08-19 CN claimed
CN-217092129-U Energy-saving distillation device for preparing 4, 6-dichloro-5-methoxypyrimidine 江苏金申医药科技有限公司 2022-08-02 CN claimed
CN-217092105-U Cooling device is used in production of 4, 6-dichloro-5-methoxy pyrimidine 江苏金申医药科技有限公司 2022-08-02 CN claimed
CN-212441190-U Environment-friendly preparation equipment of 5-methoxy-4, 6-dichloropyrimidine 常熟市金申医化制品有限责任公司 2021-02-02 CN claimed
CN-108658871-B Preparation method of sulfadoxine intermediate 4, 6-dichloro-5-methoxypyrimidine 舞阳威森生物医药有限公司 2020-10-30 CN claimed
CN-111484456-A Refining process of 5-methoxy-4, 6-dichloropyrimidine 常熟市金申医化制品有限责任公司 2020-08-04 CN claimed
CN-110256461-A Thick miscellaneous pyrimidine derivatives and its preparation method and application 江西中医药大学 2019-09-20 CN claimed
CN-110003120-A A kind of sulfadoxine and its synthetic method of stable isotope labeling 上海安谱实验科技股份有限公司 2019-07-12 CN claimed
CN-108658871-A The preparation method of sulfamethoxine intermediate 4,6- dichloro-5-methoxy pyrimidines 张家港威胜生物医药有限公司 2018-10-16 CN claimed
CN-105153044-A Method for one-pot synthesis of sulfadoxine by monitoring reaction progress through HPLC GUILIN PHARMACEUTICAL CO LTD 2015-12-16 CN claimed
CN-104370831-A Sulfadoxine production process CHANGSHU JINSHEN MEDICAL AND CHEMICAL PRODUCT CO LTD 2015-02-25 CN claimed
CN-102304094-B Preparation method of sulfadoxine and intermediate thereof CHANGSHU NANHU IND CHEMICAL CO LTD 2014-03-26 CN claimed
CN-102304095-B Preparation method of sulfadoxine CHANGSHU NANHU IND CHEMICAL CO LTD 2013-10-16 CN claimed
US-20260146124-A1 RESIN COMPOSITION AND USES OF THE SAME TAIWAN UNION TECHNOLOGY CORPORATION (TW) 2026-05-28 US disclosed
US-5077293-A Antidepressants BRISTOL-MYERS SQUIBB CO. (US) 1991-12-31 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260146124-A1 RESIN COMPOSITION AND USES OF THE SAME ARCN1, ASH2L, ITGA1 ALDH1A1 868/4885LMNA 1292/4885SMN1; SMN2 894/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.