Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.34 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL288911 | 0.84 | ALDH1A1 (0.44) | PDE5AALDH1A1LMNASMN1; SMN2AURKA | |
| SCHEMBL14782481 | 0.79 | ALDH1A1 (0.47) | PDE5AALDH1A1LMNASMN1; SMN2MAPT | |
| SCHEMBL14782257 | 0.78 | PDE5A (0.34) | PDE5AALDH1A1MAPTGAAHTT | |
| SCHEMBL7297617 | 0.77 | DHPS (0.58) | PDE5AALDH1A1HTTNFE2L2L3MBTL1 | |
| SCHEMBL12261633 | 0.76 | ALDH1A1 (0.39) | PDE5AALDH1A1LMNASMN1; SMN2AURKA | |
| SCHEMBL9044468 | 0.76 | ALDH1A1 (0.39) | PDE5AALDH1A1LMNASMN1; SMN2AURKA | |
| SCHEMBL29636952 | 0.76 | PDE5A (0.46) | PDE5AMAP4K4PI4KBL3MBTL1PIK3CD | |
| SCHEMBL16712814 | 0.76 | PDE5A (0.46) | PDE5AMAP4K4PI4KBL3MBTL1PIK3CD | |
| SCHEMBL6233405 | 0.76 | PDE5A (0.46) | PDE5ALMNAMAPTMAP4K4ADORA2A | |
| SCHEMBL7699473 | 0.75 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2MAPTMAP4K4PI4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 116 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1529036-A1 | METHOD FOR PRODUCING HIGHLY PURE CRYSTALLINE 4-AMINO-5,6-DIMETHOXYPYRIMIDINE | Degussa AG (DE) | 2005-05-11 | — | — | EP | claimed |
| WO-2004007466-A1 | METHOD FOR PRODUCING HIGHLY PURE CRYSTALLINE 4-AMINO-5,6-DIMETHOXYPYRIMIDINE | DEGUSSA AG (DE) | 2004-01-22 | — | — | WO | claimed |
| EP-4736856-A2 | BICYCLIC AMINES AS CDK2 INHIBITORS | Incyte Corporation (US) | 2026-05-06 | — | — | EP | disclosed |
| US-12570631-B2 | Substituted N-(4-(pyrimidin and pyridin-4-yl)benzylcarboxamides and its use for treating disorders responsive to inhibition of Btk | BIOGEN MA INC. (US) | 2026-03-10 | — | — | US | disclosed |
| US-20260062426-A1 | CYCLIN DEPENDENT KINASE DEGRADERS AND METHODS OF USE THEREOF | DIFFERENTIATED THERAPEUTICS INC (US) | 2026-03-05 | — | — | US | disclosed |
| EP-4041731-B1 | BICYCLIC AMINES AS CDK2 INHIBITORS | INCYTE CORP (US) | 2026-02-18 | — | — | EP | disclosed |
| US-20260022119-A1 | BICYCLIC AMINES AS CDK2 INHIBITORS | INCYTE CORPORATION | 2026-01-22 | — | — | US | disclosed |
| US-20260001898-A1 | Heteroaryl compounds as inhibitors of TYK2/JAK1, composition and application thereof | ACCRO BIOSCIENCE HK LTD (HK) | 2026-01-01 | — | — | US | disclosed |
| US-12466828-B2 | Bicyclic amines as CDK2 inhibitors | INCYTE CORPORATION (US) | 2025-11-11 | — | — | US | disclosed |
| US-12312339-B2 | Polo like kinase 4 inhibitors | ORIC PHARMACEUTICALS, INC. (US) | 2025-05-27 | — | — | US | disclosed |
| EP-4551559-A1 | HETEROARYL COMPOUNDS AS INHIBITORS OF TYK2/JAK1, COMPOSITION AND APPLICATION THEREOF | Accro Bioscience (HK) Limited (HK) | 2025-05-14 | — | — | EP | disclosed |
| US-20110059976-A1 | PYRIDO PYRIMIDINONES, DIHYDRO PYRIMIDO PYRIMIDINONES AND PTERIDINONES USEFUL AS RAF KINASE INHIBITORS | SUNESIS PHARMACEUTICALS, INC. | 2011-03-10 | — | — | US | disclosed |
| CN-101035780-A | Substituted nitrogen-containing six-membered amino-heterocycles as vanilloid-1 receptor antagonists for treating pain | MERCK SHARP & DOHME (GB) | 2007-09-12 | — | — | CN | disclosed |
| EP-1685124-A1 | SUBSTITUTED NITROGEN-CONTAINING SIX-MEMBERED AMINO-HETEROCYCLES AS VANILLOID-1 RECEPTOR ANTAGONISTS FOR TREATING PAIN | MERCK SHARP & DOHME LTD. (GB) | 2006-08-02 | — | — | EP | disclosed |
| US-20050197342-A1 | Substituted nitrogen-containing six-membered amino-heterocycles as vanilloid-1 receptor antagonists for treating pain | HOLLINGWORTH GREGORY J (GB) | 2005-09-08 | — | — | US | disclosed |
| WO-2005047279-A1 | SUBSTITUTED NITROGEN-CONTAINING SIX-MEMBERED AMINO-HETEROCYCLES AS VANILLOID-1 RECEPTOR ANTAGONISTS FOR TREATING PAIN | MERCK SHARP & DOHME LIMITED (GB) | 2005-05-26 | — | — | WO | disclosed |
| EP-1529036-A1 | METHOD FOR PRODUCING HIGHLY PURE CRYSTALLINE 4-AMINO-5,6-DIMETHOXYPYRIMIDINE | Degussa AG (DE) | 2005-05-11 | — | — | EP | disclosed |
| EP-1529036-A1 | METHOD FOR PRODUCING HIGHLY PURE CRYSTALLINE 4-AMINO-5,6-DIMETHOXYPYRIMIDINE | Degussa AG (DE) | 2005-05-11 | — | — | EP | disclosed |
| WO-2004007466-A1 | METHOD FOR PRODUCING HIGHLY PURE CRYSTALLINE 4-AMINO-5,6-DIMETHOXYPYRIMIDINE | DEGUSSA AG (DE) | 2004-01-22 | — | — | WO | disclosed |
| WO-2004007466-A1 | METHOD FOR PRODUCING HIGHLY PURE CRYSTALLINE 4-AMINO-5,6-DIMETHOXYPYRIMIDINE | DEGUSSA AG (DE) | 2004-01-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12570631-B2 | Substituted N-(4-(pyrimidin and pyridin-4-yl)benzylcarboxamides and its use for treating disorders responsive to inhibition of Btk | BTK, LYN, SYK | PDE5A 2188/4885ALDH1A1 4560/4885LMNA 1793/4885 |
| US-20050197342-A1 | Substituted nitrogen-containing six-membered amino-heterocycles as vanilloid-1 receptor antagonists for treating pain | OPRL1, OPRK1, CNR1 | PDE5A 2296/4885ALDH1A1 2879/4885LMNA 3939/4885 |
| US-20260022119-A1 | BICYCLIC AMINES AS CDK2 INHIBITORS | CCNA1, CDK1, CCNE1 | PDE5A 4549/4885ALDH1A1 1613/4885LMNA 887/4885 |
| US-20260062426-A1 | CYCLIN DEPENDENT KINASE DEGRADERS AND METHODS OF USE THEREOF | CCNA1, CCNE1, CCNA2 | PDE5A 4468/4885ALDH1A1 1035/4885LMNA 1093/4885 |
| US-12312339-B2 | Polo like kinase 4 inhibitors | PLK4, PLK2, PLK3 | PDE5A 1615/4885ALDH1A1 2211/4885LMNA 2193/4885 |
| US-20260001898-A1 | Heteroaryl compounds as inhibitors of TYK2/JAK1, composition and application thereof | JAK1, JAK2, TYK2 | PDE5A 4014/4885ALDH1A1 4319/4885LMNA 3600/4885 |
| US-20110059976-A1 | PYRIDO PYRIMIDINONES, DIHYDRO PYRIMIDO PYRIMIDINONES AND PTERIDINONES USEFUL AS RAF KINASE INHIBITORS | BRAF, RAF1, ARAF | PDE5A 1786/4885ALDH1A1 1475/4885LMNA 2071/4885 |
| US-12466828-B2 | Bicyclic amines as CDK2 inhibitors | CDK2, CDK1, CCNI | PDE5A 3123/4885ALDH1A1 2576/4885LMNA 1248/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.