Chelerythrine

Chelerythrine

SCHEMBL288915

COc1ccc2c(c[n+](C)c3c4cc5c(cc4ccc23)OCO5)c1OC

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 1.00
MAPT P10636 7/20 1.00
SMN1; SMN2 Q16637 7/20 1.00
HPGD P15428 5/20 1.00
MAPK1 P28482 5/20 1.00
KMT2A Q03164 5/20 1.00
BCHE P06276 5/20 1.00
ACHE P22303 5/20 1.00
CYP3A4 P08684 5/20 1.00
MEN1 O00255 4/20 1.00
CYP2D6 P10635 4/20 1.00
TSHR P16473 4/20 1.00
CYP1A2 P05177 4/20 1.00
TP53 P04637 3/20 1.00
ALOX15 P16050 3/20 1.00
ALOX12 P18054 3/20 1.00
HSD17B10 Q99714 3/20 1.00
TDP1 Q9NUW8 3/20 1.00
HIF1A Q16665 3/20 1.00
NPC1 O15118 2/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Chelerythrine SCHEMBL30527168 1.00 ALDH1A1 (1.00) ALDH1A1MAPTSMN1; SMN2HPGDMAPK1
Chelerythrine SCHEMBL30527167 1.00 ALDH1A1 (1.00) ALDH1A1MAPTSMN1; SMN2HPGDMAPK1
Chelerythrine SCHEMBL29357531 1.00 ALDH1A1 (1.00) ALDH1A1MAPTSMN1; SMN2HPGDMAPK1
Chelerythrine SCHEMBL30207103 0.99 ALDH1A1 (1.00) ALDH1A1MAPTSMN1; SMN2HPGDMAPK1
Chelerythrine SCHEMBL4980861 0.99 ALDH1A1 (0.98) ALDH1A1MAPTSMN1; SMN2HPGDMAPK1
Chelerythrine SCHEMBL3319851 0.99 ALDH1A1 (0.98) ALDH1A1MAPTSMN1; SMN2HPGDMAPK1
Chelerythrine SCHEMBL288916 0.99 ALDH1A1 (0.98) ALDH1A1MAPTSMN1; SMN2HPGDMAPK1
Chelerythrine SCHEMBL4016265 0.99 ALDH1A1 (0.98) ALDH1A1MAPTSMN1; SMN2HPGDMAPK1
Chelerythrine SCHEMBL195109 0.99 ALDH1A1 (1.00) ALDH1A1MAPTSMN1; SMN2HPGDMAPK1
Chelerythrine SCHEMBL3973425 0.96 ALDH1A1 (0.91) ALDH1A1MAPTSMN1; SMN2HPGDMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 3061 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122005563-A Application of chelerythrine in preparing medicines or antibiotic synergists for treating bacterial infectious diseases 扬州大学 2026-05-12 CN claimed
CN-122028938-A Pharmaceutical combination comprising an anti-CD 37 antibody maytansinoid conjugate and a BCL2 inhibitor or PI3K inhibitor 德彪药业国际股份公司 2026-05-12 CN claimed
US-12485112-B2 Pharmaceutical composition ASCLEPIUS PHARMACEUTICAL LLC (US) 2025-12-02 US claimed
EP-4260682-B1 LIGHTING METHOD FOR PROMOTING ACCUMULATION OF SECONDARY METABOLITES IN CHELIDONIUM MAJUS PLANTS LITHUANIAN RES CENTRE FOR AGRICULTURE AND FORESTRY (LT) 2025-10-29 EP claimed
WO-2025120106-A1 METHODS FOR ISOLATING EMBRYONIC STEM CELLS FROM AN AVIAN EMBRYO CELLS SUPRÊME (FR) 2025-06-12 WO claimed
EP-4567102-A1 METHODS FOR ISOLATING EMBRYONIC STEM CELLS FROM AVIAN EMBRYONIC CELLS Suprême (FR) 2025-06-11 EP claimed
US-20250163388-A1 METHODS FOR DERIVATION AND PROPAGATION OF AVIAN PLURIPOTENT STEM CELLS AND APPLICATIONS THEREOF UNIVERSITY OF SOUTHERN CALIFORNIA (US) 2025-05-22 US claimed
CN-116059227-B Macleaya cordata powder and flavonoid natural supramolecular hydrogel and application thereof as antibacterial and anti-inflammatory drugs 北京中医药大学 2025-05-13 CN claimed
CN-119977982-A 6- (N-substituted) carbamoylmethyl dihydrobenzophenanthridine alkaloid and preparation method and application thereof 湖南农业大学 2025-05-13 CN claimed
WO-2025083205-A1 DRUG COMBINATION COMPRISING ANTI-CD37 ANTIBODY MAYTANSINE CONJUGATE AND BCL2 INHIBITOR OR PI3K INHIBITOR DEBIOPHARM INTERNATIONAL S.A. (CH) 2025-04-24 WO claimed
WO-1991007391-A1 PURIFICATION OF BENZOPHENANTHRIDINE ALKALOIDS FROM ALKALOID EXTRACTS ATRIX LABORATORIES, INC. (US) 1991-05-30 WO claimed
US-5013553-A Drug delivery devices VIPONT PHARMACEUTICAL, INC. (US) 1991-05-07 US claimed
WO-1991000728-A1 BENZOPHENANTHRIDINE ALKALOIDS FOR TOPICAL ACNE TREATMENT ATRIX LABORATORIES, INC. (US) 1991-01-24 WO claimed
EP-0396232-A2 Oral rinse compositions VIPONT PHARMACEUTICAL, INC. (US) 1990-11-07 EP claimed
EP-0297535-A2 Drug delivery devices VIPONT PHARMACEUTICAL, INC. (US) 1989-01-04 EP claimed
US-4769452-A Production of purity benzo-c-phenanthridine alkaloid salts VIPONT LABORATORIES, INC. (US) 1988-09-06 US claimed
US-4767626-A ALKALOID EXTRACT OF ZANTHOXYLUM SIMULANS CHENG THEODORE (US) 1988-08-30 US claimed
US-4767861-A Recovery of benzo-c-phenanthridine alkaloids VIPONT LABORATORIES (US) 1988-08-30 US claimed
US-4683133-A PUMPING ALKALOID SALT SOLUTIONS ON GUMS VIPONT LABORATORIES, INC. (US) 1987-07-28 US claimed
US-4590061-A BENZO-C-PHENANTHRIDINE ALKALOIDS VIPONT LABORATORIES, INC. (US) 1986-05-20 US claimed