Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Chelerythrine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.98 |
| ▸ | MAPT | P10636 | 7/20 | 0.98 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.98 |
| ▸ | HPGD | P15428 | 5/20 | 0.98 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.98 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.98 |
| ▸ | BCHE | P06276 | 5/20 | 0.98 |
| ▸ | ACHE | P22303 | 5/20 | 0.98 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.98 |
| ▸ | MEN1 | O00255 | 4/20 | 0.98 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.98 |
| ▸ | TSHR | P16473 | 4/20 | 0.98 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.98 |
| ▸ | TP53 | P04637 | 3/20 | 0.98 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.98 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.98 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.98 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.98 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.98 |
| ▸ | NPC1 | O15118 | 2/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chelerythrine SCHEMBL30527167 | 0.99 | ALDH1A1 (1.00) | ALDH1A1MAPTSMN1; SMN2HPGDMAPK1 | |
| Chelerythrine SCHEMBL29357531 | 0.99 | ALDH1A1 (1.00) | ALDH1A1MAPTSMN1; SMN2HPGDMAPK1 | |
| Chelerythrine SCHEMBL30527168 | 0.99 | ALDH1A1 (1.00) | ALDH1A1MAPTSMN1; SMN2HPGDMAPK1 | |
| Chelerythrine SCHEMBL288915 | 0.99 | ALDH1A1 (1.00) | ALDH1A1MAPTSMN1; SMN2HPGDMAPK1 | |
| Chelerythrine SCHEMBL30207103 | 0.98 | ALDH1A1 (1.00) | ALDH1A1MAPTSMN1; SMN2HPGDMAPK1 | |
| Chelerythrine SCHEMBL4016265 | 0.98 | ALDH1A1 (0.98) | ALDH1A1MAPTSMN1; SMN2HPGDMAPK1 | |
| Chelerythrine SCHEMBL195109 | 0.98 | ALDH1A1 (1.00) | ALDH1A1MAPTSMN1; SMN2HPGDMAPK1 | |
| Chelerythrine SCHEMBL4980861 | 0.98 | ALDH1A1 (0.98) | ALDH1A1MAPTSMN1; SMN2HPGDMAPK1 | |
| Chelerythrine SCHEMBL3319851 | 0.98 | ALDH1A1 (0.98) | ALDH1A1MAPTSMN1; SMN2HPGDMAPK1 | |
| Chelerythrine SCHEMBL3973425 | 0.94 | ALDH1A1 (0.91) | ALDH1A1MAPTSMN1; SMN2HPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 3014 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122028938-A | Pharmaceutical combination comprising an anti-CD 37 antibody maytansinoid conjugate and a BCL2 inhibitor or PI3K inhibitor | 德彪药业国际股份公司 | 2026-05-12 | — | — | CN | claimed |
| CN-122005563-A | Application of chelerythrine in preparing medicines or antibiotic synergists for treating bacterial infectious diseases | 扬州大学 | 2026-05-12 | — | — | CN | claimed |
| US-12485112-B2 | Pharmaceutical composition | ASCLEPIUS PHARMACEUTICAL LLC (US) | 2025-12-02 | — | — | US | claimed |
| EP-4260682-B1 | LIGHTING METHOD FOR PROMOTING ACCUMULATION OF SECONDARY METABOLITES IN CHELIDONIUM MAJUS PLANTS | LITHUANIAN RES CENTRE FOR AGRICULTURE AND FORESTRY (LT) | 2025-10-29 | — | — | EP | claimed |
| WO-2025120106-A1 | METHODS FOR ISOLATING EMBRYONIC STEM CELLS FROM AN AVIAN EMBRYO CELLS | SUPRÊME (FR) | 2025-06-12 | — | — | WO | claimed |
| EP-4567102-A1 | METHODS FOR ISOLATING EMBRYONIC STEM CELLS FROM AVIAN EMBRYONIC CELLS | Suprême (FR) | 2025-06-11 | — | — | EP | claimed |
| US-20250163388-A1 | METHODS FOR DERIVATION AND PROPAGATION OF AVIAN PLURIPOTENT STEM CELLS AND APPLICATIONS THEREOF | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2025-05-22 | — | — | US | claimed |
| CN-119977982-A | 6- (N-substituted) carbamoylmethyl dihydrobenzophenanthridine alkaloid and preparation method and application thereof | 湖南农业大学 | 2025-05-13 | — | — | CN | claimed |
| CN-116059227-B | Macleaya cordata powder and flavonoid natural supramolecular hydrogel and application thereof as antibacterial and anti-inflammatory drugs | 北京中医药大学 | 2025-05-13 | — | — | CN | claimed |
| WO-2025083205-A1 | DRUG COMBINATION COMPRISING ANTI-CD37 ANTIBODY MAYTANSINE CONJUGATE AND BCL2 INHIBITOR OR PI3K INHIBITOR | DEBIOPHARM INTERNATIONAL S.A. (CH) | 2025-04-24 | — | — | WO | claimed |
| WO-1991007391-A1 | PURIFICATION OF BENZOPHENANTHRIDINE ALKALOIDS FROM ALKALOID EXTRACTS | ATRIX LABORATORIES, INC. (US) | 1991-05-30 | — | — | WO | claimed |
| US-5013553-A | Drug delivery devices | VIPONT PHARMACEUTICAL, INC. (US) | 1991-05-07 | — | — | US | claimed |
| WO-1991000728-A1 | BENZOPHENANTHRIDINE ALKALOIDS FOR TOPICAL ACNE TREATMENT | ATRIX LABORATORIES, INC. (US) | 1991-01-24 | — | — | WO | claimed |
| EP-0396232-A2 | Oral rinse compositions | VIPONT PHARMACEUTICAL, INC. (US) | 1990-11-07 | — | — | EP | claimed |
| EP-0297535-A2 | Drug delivery devices | VIPONT PHARMACEUTICAL, INC. (US) | 1989-01-04 | — | — | EP | claimed |
| US-4769452-A | Production of purity benzo-c-phenanthridine alkaloid salts | VIPONT LABORATORIES, INC. (US) | 1988-09-06 | — | — | US | claimed |
| US-4767626-A | ALKALOID EXTRACT OF ZANTHOXYLUM SIMULANS | CHENG THEODORE (US) | 1988-08-30 | — | — | US | claimed |
| US-4767861-A | Recovery of benzo-c-phenanthridine alkaloids | VIPONT LABORATORIES (US) | 1988-08-30 | — | — | US | claimed |
| US-4683133-A | PUMPING ALKALOID SALT SOLUTIONS ON GUMS | VIPONT LABORATORIES, INC. (US) | 1987-07-28 | — | — | US | claimed |
| US-4590061-A | BENZO-C-PHENANTHRIDINE ALKALOIDS | VIPONT LABORATORIES, INC. (US) | 1986-05-20 | — | — | US | claimed |