Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.91 |
| ▸ | MAPT | P10636 | 7/20 | 0.91 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.91 |
| ▸ | HPGD | P15428 | 5/20 | 0.91 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.91 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.91 |
| ▸ | BCHE | P06276 | 5/20 | 0.91 |
| ▸ | ACHE | P22303 | 5/20 | 0.91 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.91 |
| ▸ | MEN1 | O00255 | 4/20 | 0.91 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.91 |
| ▸ | TSHR | P16473 | 4/20 | 0.91 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.91 |
| ▸ | TP53 | P04637 | 3/20 | 0.91 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.91 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.91 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.91 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.91 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.91 |
| ▸ | NPC1 | O15118 | 2/20 | 0.91 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chelerythrine SCHEMBL30527168 | 0.96 | ALDH1A1 (1.00) | ALDH1A1MAPTSMN1; SMN2HPGDMAPK1 | |
| Chelerythrine SCHEMBL29357531 | 0.96 | ALDH1A1 (1.00) | ALDH1A1MAPTSMN1; SMN2HPGDMAPK1 | |
| Chelerythrine SCHEMBL30527167 | 0.96 | ALDH1A1 (1.00) | ALDH1A1MAPTSMN1; SMN2HPGDMAPK1 | |
| Chelerythrine SCHEMBL288915 | 0.96 | ALDH1A1 (1.00) | ALDH1A1MAPTSMN1; SMN2HPGDMAPK1 | |
| Chelerythrine SCHEMBL3319851 | 0.94 | ALDH1A1 (0.98) | ALDH1A1MAPTSMN1; SMN2HPGDMAPK1 | |
| Chelerythrine SCHEMBL30207103 | 0.94 | ALDH1A1 (1.00) | ALDH1A1MAPTSMN1; SMN2HPGDMAPK1 | |
| Chelerythrine SCHEMBL4980861 | 0.94 | ALDH1A1 (0.98) | ALDH1A1MAPTSMN1; SMN2HPGDMAPK1 | |
| Chelerythrine SCHEMBL4016265 | 0.94 | ALDH1A1 (0.98) | ALDH1A1MAPTSMN1; SMN2HPGDMAPK1 | |
| Chelerythrine SCHEMBL195109 | 0.94 | ALDH1A1 (1.00) | ALDH1A1MAPTSMN1; SMN2HPGDMAPK1 | |
| Chelerythrine SCHEMBL288916 | 0.94 | ALDH1A1 (0.98) | ALDH1A1MAPTSMN1; SMN2HPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057149-B1 | PSEUDOBASE BENZO [C]PHENANTHRIDINES WITH IMPROVED EFFICACY, STABILITY, AND SAFETY | UNIV YALE (US) | 2014-10-29 | — | — | EP | disclosed |
| EP-2057149-A2 | PSEUDOBASE BENZO [C]PHENANTHRIDINES WITH IMPROVED EFFICACY, STABILITY, AND SAFETY | Marinus Pharmaceuticals, Inc. (US) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008016596-A2 | PSEUDOBASE BENZO [C] PHENANTHRIDINES WITH IMPROVED EFFICACY, STABILITY, AND SAFETY | MARINUS PHARMACEUTICALS, INC. (US) | 2008-02-07 | — | — | WO | disclosed |