Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | PDE7A | Q13946 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8652013 | 0.89 | KMT2A (0.40) | KMT2ARAB9ANPC1PDE7APOLB | |
| SCHEMBL8645554 | 0.88 | KMT2A (0.38) | KMT2ARAB9ANPC1PDE7APOLB | |
| SCHEMBL5437164 | 0.88 | KMT2A (0.38) | KMT2ARAB9ANPC1PDE7APOLB | |
| SCHEMBL5107358 | 0.88 | KMT2A (0.35) | KMT2ARAB9ANPC1PDE7AMAPT | |
| SCHEMBL3001186 | 0.85 | KMT2A (0.36) | KMT2APDE7ASMN1; SMN2LMNA | |
| SCHEMBL2886584 | 0.84 | ACACB (0.33) | KMT2A | |
| SCHEMBL1475886 | 0.84 | KMT2A (0.37) | KMT2ARAB9ANPC1PDE7APOLB | |
| SCHEMBL3077698 | 0.81 | THRB (0.37) | KMT2APDE7AMAPTSMN1; SMN2LMNA | |
| SCHEMBL3176738 | 0.80 | PDE7A (0.35) | KMT2ARAB9ANPC1PDE7APOLB | |
| SCHEMBL12496896 | 0.79 | PDE7A (0.40) | KMT2ARAB9APDE7APOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7727933-B2 | 2-ethyl-4,6-dimethyl-phenyl-substituted spirocyclic tetramic acid derivatives | BAYER CROPSCIENCE AG (DE) | 2010-06-01 | — | — | US | disclosed |
| US-20070298969-A1 | 2-Ethyl-4,6-Dimethyl-Phenyl-Substituted Spirocyclic Tetramic Acid Derivatives | BAYER CROPSCIENCE AKTIENGESELLSCHAFF (DE) | 2007-12-27 | — | — | US | disclosed |
| EP-1687272-A1 | 2-ETHYL-4,6-DIMETHYL-PHENYL-SUBSTITUTED SPIROCYCLIC TETRAMIC ACID DERIVATIVES | Bayer CropScience AG (DE) | 2006-08-09 | — | — | EP | disclosed |
| WO-2005049569-A1 | 2-ETHYL-4,6-DIMETHYL-PHENYL-SUBSTITUTED SPIROCYCLIC TETRAMIC ACID DERIVATIVES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2005-06-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070298969-A1 | 2-Ethyl-4,6-Dimethyl-Phenyl-Substituted Spirocyclic Tetramic Acid Derivatives | DDT, PKD2, CYP2D6 | KMT2A 1977/4885RAB9A 1918/4885NPC1 3871/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.