Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bromfenac. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.97 |
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.97 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.97 |
| ▸ | LMNA | P02545 | 1/20 | 0.97 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.97 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromfenac SCHEMBL34411 | 0.99 | ABCB11 (1.00) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| Bromfenac SCHEMBL14861906 | 0.99 | ABCB11 (1.00) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| Bromfenac SCHEMBL28429917 | 0.97 | ABCB11 (0.97) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| Bromfenac SCHEMBL28429415 | 0.97 | ABCB11 (0.97) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| Bromfenac SCHEMBL4603047 | 0.97 | ABCB11 (0.97) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| Bromfenac SCHEMBL57092 | 0.97 | ABCB11 (0.97) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| Bromfenac SCHEMBL57090 | 0.97 | ABCB11 (0.97) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| Bromfenac SCHEMBL28429368 | 0.97 | ABCB11 (0.97) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| Bromfenac SCHEMBL28420990 | 0.97 | ABCB11 (0.97) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| Bromfenac SCHEMBL15968905 | 0.97 | ABCB11 (0.97) | ABCB11LMNAPTGS1ADORA1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111743878-B | Compositions and methods for ophthalmic and/or other applications | 卡拉制药公司 | 2023-04-11 | — | — | CN | disclosed |
| CN-111743878-A | Compositions and methods for ophthalmic and/or other applications | 卡拉制药公司 | 2020-10-09 | — | — | CN | disclosed |
| CN-111743879-A | Compositions and methods for ophthalmic and/or other applications | 卡拉制药公司 | 2020-10-09 | — | — | CN | disclosed |
| CN-111714472-A | Drug nanoparticles exhibiting enhanced mucosal transport | 卡拉制药公司 | 2020-09-29 | — | — | CN | disclosed |
| CN-111700878-A | Drug nanoparticles exhibiting enhanced mucosal transport | 卡拉制药公司 | 2020-09-25 | — | — | CN | disclosed |
| CN-111700879-A | Drug nanoparticles exhibiting enhanced mucosal transport | 卡拉制药公司 | 2020-09-25 | — | — | CN | disclosed |
| CN-111700880-A | Drug nanoparticles exhibiting enhanced mucosal transport | 卡拉制药公司 | 2020-09-25 | — | — | CN | disclosed |
| CN-105916509-B | Compositions and methods for ophthalmic and/or other applications | 卡拉制药公司 | 2020-07-17 | — | — | CN | disclosed |