Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bromfenac. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.97 |
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.97 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.97 |
| ▸ | LMNA | P02545 | 1/20 | 0.97 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.97 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromfenac SCHEMBL15968905 | 1.00 | ABCB11 (0.97) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| Bromfenac SCHEMBL29023565 | 0.99 | ABCB11 (0.94) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| Bromfenac SCHEMBL14861906 | 0.99 | ABCB11 (1.00) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| Bromfenac SCHEMBL34411 | 0.99 | ABCB11 (1.00) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| Bromfenac SCHEMBL57092 | 0.97 | ABCB11 (0.97) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| Bromfenac SCHEMBL28429368 | 0.97 | ABCB11 (0.97) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| Bromfenac SCHEMBL28895435 | 0.97 | ABCB11 (0.97) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| Bromfenac SCHEMBL28429415 | 0.97 | ABCB11 (0.97) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| Bromfenac SCHEMBL28420990 | 0.97 | ABCB11 (0.97) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| Bromfenac SCHEMBL28429917 | 0.97 | ABCB11 (0.97) | ABCB11LMNAPTGS1ADORA1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111743858-B | Pharmaceutical composition of bromfenac sodium | 天津药业研究院股份有限公司 | 2023-06-27 | — | — | CN | claimed |
| CN-110885296-B | Preparation method of bromfenac sodium | 新发药业有限公司 | 2022-11-04 | — | — | CN | claimed |
| US-9561277-B2 | Aqueous liquid preparation containing 2-amino-3-(4-bromobenzoyl)phenylacetic acid | SENJU PHARMACEUTICAL CO., LTD. (JP) | 2017-02-07 | — | — | US | claimed |
| WO-2015170177-A1 | AQUEOUS LIQUID PREPARATION CONTAINING 2-AMINO-3-(4-BROMOBENZOYL)PHENYLACETIC ACID | SENJU PHARMACEUTICAL CO., LTD. (JP) | 2015-11-12 | — | — | WO | claimed |
| US-9144609-B2 | Aqueous liquid preparation containing 2-amino-3-(4-bromobenzoyl)phenylacetic acid | SENJU PHARMACEUTICAL CO., LTD. (JP) | 2015-09-29 | — | — | US | claimed |
| US-20150025149-A1 | AQUEOUS LIQUID PREPARATION CONTAINING 2-AMINO-3-(4-BROMOBENZOYL)PHENYLACETIC ACID | SENJU PHARMACEUTICAL CO., LTD. (JP) | 2015-01-22 | — | — | US | claimed |
| US-20150011634-A1 | AQUEOUS LIQUID PREPARATION CONTAINING 2-AMINO-3-(4-BROMOBENZOYL)PHENYLACETIC ACID | SENJU PHARMACEUTICAL CO., LTD. (JP) | 2015-01-08 | — | — | US | claimed |
| US-8927606-B1 | Aqueous liquid preparation containing 2-amino-3-(4-bromobenzoyl)phenylacetic acid | SENJU PHARMACEUTICAL CO., LTD. (JP) | 2015-01-06 | — | — | US | claimed |
| US-8871813-B2 | Aqueous liquid preparation containing 2-amino-3-(4-bromobenzoyl)phenylacetic acid | SENJU PHARMACEUTICAL CO., LTD. (JP) | 2014-10-28 | — | — | US | claimed |
| US-20140243413-A1 | AQUEOUS LIQUID PREPARATION CONTAINING 2-AMINO-3-(4-BROMOBENZOYL)PHENYLACETIC ACID | SENJU PHARMACEUTICAL CO., LTD. (JP) | 2014-08-28 | — | — | US | claimed |
| US-20140235721-A1 | AQUEOUS LIQUID PREPARATION CONTAINING 2-AMINO-3-(4-BROMOBENZOYL)PHENYLACETIC ACID | SENJU PHARMACEUTICAL CO., LTD. (JP) | 2014-08-21 | — | — | US | claimed |
| US-8754131-B2 | Aqueous liquid preparation containing 2-amino-3-(4-bromobenzoyl)phenylacetic acid | SENJU PHARMACEUTICAL CO., LTD. (JP) | 2014-06-17 | — | — | US | claimed |
| US-20140142183-A1 | AQUEOUS LIQUID PREPARATION CONTAINING 2-AMINO-3-(4-BROMOBENZOYL)PHENYLACETIC ACID | SENJU PHARMACEUTICAL CO., LTD. (JP) | 2014-05-22 | — | — | US | claimed |
| US-8669290-B2 | Aqueous liquid preparation containing 2-amino-3-(4-bromobenzoyl)phenylacetic acid | SENJU PHARMACEUTICAL CO., LTD. (JP) | 2014-03-11 | — | — | US | claimed |
| US-8497304-B2 | Aqueous liquid preparation containing 2-amino-3-(4-bromobenzoyl)phenylacetic acid | SENJU PHARMACEUTICAL CO., LTD. (JP) | 2013-07-30 | — | — | US | claimed |
| US-20130090384-A1 | AQUEOUS LIQUID PREPARATION CONTAINING 2-AMINO-3-(4-BROMOBENZOYL)PHENYLACETIC ACID | SENJU PHARMACEUTICAL CO., LTD. (JP) | 2013-04-11 | — | — | US | claimed |
| US-20120115957-A1 | AQUEOUS LIQUID PREPARATION CONTAINING 2-AMINO-3-(4-BROMOBENZOYL)PHENYLACETIC ACID | SENJU PHARMACEUTICAL CO., LTD. (JP) | 2012-05-10 | — | — | US | claimed |
| US-8129431-B2 | Aqueous liquid preparation containing 2-amino-3-(4-bromobenzoyl)phenylacetic acid | SENJU PHARMACEUTICAL CO., LTD. (JP) | 2012-03-06 | — | — | US | claimed |
| CN-115477611-B | MRGPRX2 antagonists for the treatment of pseudoallergy | 香港大学 | 2024-11-08 | — | — | CN | disclosed |
| US-4683242-A | Transdermal treatment for pain and inflammation with 2-amino-3-aroylbenzeneacetic acids, salts and esters | A. H. ROBINS COMPANY, INCORPORATED (US) | 1987-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140243413-A1 | AQUEOUS LIQUID PREPARATION CONTAINING 2-AMINO-3-(4-BROMOBENZOYL)PHENYLACETIC ACID | AADAT, TLR2, FFAR2 | PTGS1 132/4885PTGS2 61/4885ABCB11 1324/4885 |
| US-20140142183-A1 | AQUEOUS LIQUID PREPARATION CONTAINING 2-AMINO-3-(4-BROMOBENZOYL)PHENYLACETIC ACID | PAOX, FFAR2, FFAR3 | PTGS1 149/4885PTGS2 60/4885ABCB11 952/4885 |
| US-20130090384-A1 | AQUEOUS LIQUID PREPARATION CONTAINING 2-AMINO-3-(4-BROMOBENZOYL)PHENYLACETIC ACID | PAOX, FFAR2, FFAR3 | PTGS1 149/4885PTGS2 60/4885ABCB11 952/4885 |
| US-20140235721-A1 | AQUEOUS LIQUID PREPARATION CONTAINING 2-AMINO-3-(4-BROMOBENZOYL)PHENYLACETIC ACID | PAOX, FFAR2, FFAR3 | PTGS1 149/4885PTGS2 60/4885ABCB11 952/4885 |
| US-20150025149-A1 | AQUEOUS LIQUID PREPARATION CONTAINING 2-AMINO-3-(4-BROMOBENZOYL)PHENYLACETIC ACID | PAOX, FFAR2, FFAR3 | PTGS1 149/4885PTGS2 60/4885ABCB11 952/4885 |
| US-20150011634-A1 | AQUEOUS LIQUID PREPARATION CONTAINING 2-AMINO-3-(4-BROMOBENZOYL)PHENYLACETIC ACID | PAOX, FFAR2, FFAR3 | PTGS1 149/4885PTGS2 60/4885ABCB11 952/4885 |
| US-20120115957-A1 | AQUEOUS LIQUID PREPARATION CONTAINING 2-AMINO-3-(4-BROMOBENZOYL)PHENYLACETIC ACID | PAOX, FFAR2, FFAR3 | PTGS1 149/4885PTGS2 60/4885ABCB11 952/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.