Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bromfenac. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 1.00 |
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | ADORA1 | P30542 | 1/20 | 1.00 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromfenac SCHEMBL14861906 | 1.00 | ABCB11 (1.00) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| Bromfenac SCHEMBL28420990 | 0.99 | ABCB11 (0.97) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| Bromfenac SCHEMBL28429368 | 0.99 | ABCB11 (0.97) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| Bromfenac SCHEMBL28895435 | 0.99 | ABCB11 (0.97) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| Bromfenac SCHEMBL28429415 | 0.99 | ABCB11 (0.97) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| Bromfenac SCHEMBL57092 | 0.99 | ABCB11 (0.97) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| Bromfenac SCHEMBL57090 | 0.99 | ABCB11 (0.97) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| Bromfenac SCHEMBL15968905 | 0.99 | ABCB11 (0.97) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| Bromfenac SCHEMBL28429917 | 0.99 | ABCB11 (0.97) | ABCB11LMNAPTGS1ADORA1PTGS2 | |
| Bromfenac SCHEMBL4603047 | 0.99 | ABCB11 (0.97) | ABCB11LMNAPTGS1ADORA1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 14427 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4724839-A2 | CONTACT LENSES INCLUDING MEDICAMENTS AND METHODS OF MAKING AND USING SAME INCLUDING SLOW RELEASE OF GLAUCOMA TREATING DRUGS AND COMFORT ENHANCING DRUGS | Mediprint Ophthalmics Inc. (US) | 2026-04-15 | — | — | EP | claimed |
| US-12594351-B2 | Methods for increasing shelf-life of ophthalmic pharmaceutical compositions | HARROW IP LLC (US) | 2026-04-07 | — | — | US | claimed |
| US-20260090984-A1 | CONTACT LENSES INCLUDING MEDICAMENTS AND METHODS OF MAKING AND USING SAME INCLUDING SLOW RELEASE OF GLAUCOMA TREATING DRUGS AND COMFORT ENHANCING DRUGS | MEDIPRINT OPHTHALMICS INC. (US) | 2026-04-02 | — | — | US | claimed |
| US-20260091018-A1 | COMBINATION PREPARATION CONTAINING HETEROCYCLIDENE ACETAMIDE DERIVATIVE | SENJU PHARMACEUTICAL CO., LTD. (JP) | 2026-04-02 | — | — | US | claimed |
| US-20260076872-A1 | POLYMER VIALS WITH SUBSTANTIALLY FLAT BOTTOMS AND INJECTION STRETCH BLOW MOLDING METHODS FOR MAKING THE SAME | SIO2 MEDICAL PRODUCTS LLC (US) | 2026-03-19 | — | — | US | claimed |
| US-12569451-B2 | Bio-inspired tissue-adhesive hydrogel patch and uses thereof | Cellartgen Inc. (KR) | 2026-03-10 | — | — | US | claimed |
| US-12527767-B2 | Eye drops to treat chemically induced corneal damage | THE CURATORS OF THE UNIVERSITY OF MISSOURI (US) | 2026-01-20 | — | — | US | claimed |
| US-20260000741-A1 | METHOD OF AMELIORATING A PRO-INFLAMMATORY IMMUNOPHENOTYPE IN FARBER DISEASE SUBJECTS BY REPEATED ADMINISTRATION OF A RECOMBINANT HUMAN ACID CERAMIDASE | ACERAGEN INC (US) | 2026-01-01 | — | — | US | claimed |
| US-20250381201-A1 | COMPOSITIONS AND METHODS FOR TREATING EYES AND METHODS OF PREPARATION | OCULAR SCIENCE INC (US) | 2025-12-18 | — | — | US | claimed |
| US-20250345274-A1 | ALKALI METAL SALT COMBINATIONS OF INCOMPATIBLE ACTIVE PHARMACEUTICAL INGREDIENTS | HALEON US HOLDINGS LLC (US) | 2025-11-13 | — | — | US | claimed |
| EP-0739197-A1 | PRESERVED OPHTHALMIC DRUG COMPOSITIONS CONTAINING POLYMERIC QUATERNARY AMMONIUM COMPOUNDS | ALCON LABORATORIES, INC. (US) | 1996-10-30 | — | — | EP | claimed |
| WO-1996030022-A1 | TOPICAL OPHTHALMIC FORMULATIONS COMPRISING AN ACIDIC DRUG, VITAMIN E TPGS, BENZALKONIUM CHLORIDE AND CAFFEINE | ALCON LABORATORIES, INC. (US) | 1996-10-03 | — | — | WO | claimed |
| EP-0734248-A1 | IMPROVED INTRAOCULAR IRRIGATING SOLUTION CONTAINING NON-STEROIDAL ANTIINFLAMMATORY AGENT | ALCON LABORATORIES, INC. (US) | 1996-10-02 | — | — | EP | claimed |
| US-5558876-A | IMPROVED STABILITY AND COMFORT, VITAMIN E TOCOPHEROL POLYETHYLENE GLYCOL SUCCINATE | ALCON LABORATORIES, INC. (US) | 1996-09-24 | — | — | US | claimed |
| WO-1996020187-A2 | ESTERS AND AMIDES OF NON-STEROIDAL ANTI-INFLAMMATORY CARBOXYLIC ACIDS WHICH MAY BE USED AS ANTI-OXIDANTS, 5-LIPOXYGENASE INHIBITORS AND NON-STEROIDAL ANTI-INFLAMMATORY PRODUCTS | ALCON LABORATORIES, INC. (US) | 1996-07-04 | — | — | WO | claimed |
| WO-1996014829-A1 | PRESERVED OPHTHALMIC DRUG COMPOSITIONS CONTAINING POLYMERIC QUATERNARY AMMONIUM COMPOUNDS | ALCON LABORATORIES, INC. (US) | 1996-05-23 | — | — | WO | claimed |
| WO-1995016435-A2 | IMPROVED INTRAOCULAR IRRIGATING SOLUTION CONTAINING NON-STEROIDAL ANTIINFLAMMATORY AGENT | ALCON LABORATORIES, INC. (US) | 1995-06-22 | — | — | WO | claimed |
| EP-0221753-B1 | TRANSDERMAL TREATMENT FOR PAIN AND INFLAMMATION WITH 2-AMINO-3-AROYLBENZENEACETIC ACIDS, SALTS AND ESTERS | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) (US) | 1992-01-08 | — | — | EP | claimed |
| US-4683242-A | Transdermal treatment for pain and inflammation with 2-amino-3-aroylbenzeneacetic acids, salts and esters | A. H. ROBINS COMPANY, INCORPORATED (US) | 1987-07-28 | — | — | US | claimed |
| EP-0221753-A2 | Transdermal treatment for pain and inflammation with 2-amino-3-aroylbenzeneacetic acids, salts and esters | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) (US) | 1987-05-13 | — | — | EP | claimed |