Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.33 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.33 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1536614 | 0.78 | ALDH1A1 (0.44) | KMT2ANUDT1SMN1; SMN2KDM4ELMNA | |
| SCHEMBL28896573 | 0.76 | KDM4E (0.34) | KMT2ANUDT1SMN1; SMN2KDM4ENPSR1 | |
| SCHEMBL28896275 | 0.75 | KDM4E (0.35) | KMT2ANUDT1SMN1; SMN2KDM4ENPSR1 | |
| SCHEMBL1536739 | 0.74 | TSHR (0.45) | KMT2ANUDT1SMN1; SMN2KDM4ELMNA | |
| SCHEMBL28896253 | 0.74 | NUDT1 (0.38) | KMT2ANUDT1SMN1; SMN2KDM4ELMNA | |
| SCHEMBL28896250 | 0.74 | PTGER4 (0.38) | KMT2ANUDT1SMN1; SMN2KDM4ENPSR1 | |
| SCHEMBL1536764 | 0.73 | LMNA (0.44) | KMT2ANUDT1SMN1; SMN2KDM4ENPSR1 | |
| Hydrochloric Acid SCHEMBL25312311 | 0.73 | TSHR (0.44) | KMT2ANUDT1SMN1; SMN2KDM4ELMNA | |
| SCHEMBL18557963 | 0.73 | KMT2A (0.43) | KMT2ANUDT1SMN1; SMN2KDM4ELMNA | |
| SCHEMBL21530644 | 0.72 | TSHR (0.46) | KMT2ANUDT1SMN1; SMN2KDM4ENPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115403584-B | 2-thio-2, 3-dihydropyrimidine-4-one derivatives, pharmaceutical compositions, preparation methods and applications thereof | 长春金赛药业有限责任公司 | 2024-04-02 | — | — | CN | disclosed |
| CN-115403584-A | 2-thio-2, 3-dihydropyrimidine-4-one derivative, pharmaceutical composition, preparation method and application thereof | 长春金赛药业有限责任公司 | 2022-11-29 | — | — | CN | disclosed |