Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.32 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28896256 | 0.84 | MAPT (0.36) | KDM4ENPSR1SMN1; SMN2PDK1PDK2 | |
| SCHEMBL28896575 | 0.84 | LMNA (0.33) | KDM4EKMT2ANUDT1SMN1; SMN2ALDH1A1 | |
| SCHEMBL28896488 | 0.80 | SMN1; SMN2 (0.36) | KDM4ENPSR1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL28896261 | 0.79 | KDM4E (0.34) | KDM4ENPSR1JAK2JAK3KMT2A | |
| SCHEMBL28896250 | 0.77 | PTGER4 (0.38) | KDM4ENPSR1JAK2JAK3KMT2A | |
| SCHEMBL1536614 | 0.76 | ALDH1A1 (0.44) | KDM4EKMT2ANUDT1SMN1; SMN2ALDH1A1 | |
| SCHEMBL28896207 | 0.76 | KMT2A (0.34) | KDM4ENPSR1KMT2ANUDT1SMN1; SMN2 | |
| SCHEMBL28896275 | 0.73 | KDM4E (0.35) | KDM4ENPSR1KMT2ANUDT1SMN1; SMN2 | |
| SCHEMBL29211269 | 0.72 | KMT2A (0.34) | KDM4ENPSR1KMT2ANUDT1SMN1; SMN2 | |
| SCHEMBL4200796 | 0.71 | ALDH1A1 (0.45) | KDM4EKMT2ANUDT1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115403584-B | 2-thio-2, 3-dihydropyrimidine-4-one derivatives, pharmaceutical compositions, preparation methods and applications thereof | 长春金赛药业有限责任公司 | 2024-04-02 | — | — | CN | disclosed |
| CN-115403584-A | 2-thio-2, 3-dihydropyrimidine-4-one derivative, pharmaceutical composition, preparation method and application thereof | 长春金赛药业有限责任公司 | 2022-11-29 | — | — | CN | disclosed |