Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1584098 | 0.80 | TSHR (0.48) | TSHRL3MBTL1ALDH1A1KDM4ELMNA | |
| SCHEMBL7412000 | 0.78 | DPP4 (0.51) | TSHRL3MBTL1ALDH1A1KDM4ELMNA | |
| SCHEMBL7497591 | 0.78 | DPP4 (0.51) | TSHRL3MBTL1ALDH1A1KDM4ELMNA | |
| SCHEMBL22440090 | 0.78 | TSHR (0.46) | TSHRL3MBTL1ALDH1A1KDM4ELMNA | |
| SCHEMBL10732370 | 0.77 | TSHR (0.44) | TSHRL3MBTL1ALDH1A1KDM4EKMT2A | |
| SCHEMBL9003054 | 0.77 | KMT2A (0.68) | TSHRL3MBTL1ALDH1A1KDM4ELMNA | |
| SCHEMBL9003051 | 0.77 | KMT2A (0.68) | TSHRL3MBTL1ALDH1A1KDM4ELMNA | |
| SCHEMBL23925182 | 0.76 | TSHR (0.50) | TSHRL3MBTL1ALDH1A1KDM4ELMNA | |
| SCHEMBL1343753 | 0.75 | L3MBTL1 (0.44) | TSHRL3MBTL1ALDH1A1KDM4ELMNA | |
| SCHEMBL2299168 | 0.75 | DPP4 (0.53) | TSHRL3MBTL1ALDH1A1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107098886-B | Prazinone-containing quinazolinone PARP-1/2 inhibitor and preparation method, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2020-07-14 | — | — | CN | disclosed |