Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28896573 | 0.84 | KDM4E (0.34) | LMNASMN1; SMN2KMT2ANUDT1MAOA | |
| SCHEMBL28896258 | 0.83 | MAPT (0.36) | LMNASMN1; SMN2ALDH1A1KDM4EMAPT | |
| SCHEMBL28896489 | 0.80 | SMN1; SMN2 (0.37) | LMNASMN1; SMN2KMT2AALDH1A1POLB | |
| SCHEMBL28896253 | 0.77 | NUDT1 (0.38) | LMNASMN1; SMN2KMT2ANUDT1ALDH1A1 | |
| SCHEMBL1536614 | 0.77 | ALDH1A1 (0.44) | LMNASMN1; SMN2KMT2ANUDT1MAOA | |
| SCHEMBL28896263 | 0.76 | SMN1; SMN2 (0.33) | LMNASMN1; SMN2KMT2ANUDT1ALDH1A1 | |
| SCHEMBL25241521 | 0.72 | KDM4E (0.51) | LMNAKMT2ANUDT1ALDH1A1GAA | |
| SCHEMBL18557963 | 0.72 | KMT2A (0.43) | LMNASMN1; SMN2KMT2ANUDT1CYP1A2 | |
| SCHEMBL4200796 | 0.72 | ALDH1A1 (0.45) | LMNASMN1; SMN2KMT2ANUDT1ALDH1A1 | |
| SCHEMBL28896275 | 0.72 | KDM4E (0.35) | LMNASMN1; SMN2KMT2ANUDT1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115403584-B | 2-thio-2, 3-dihydropyrimidine-4-one derivatives, pharmaceutical compositions, preparation methods and applications thereof | 长春金赛药业有限责任公司 | 2024-04-02 | — | — | CN | disclosed |
| CN-115403584-A | 2-thio-2, 3-dihydropyrimidine-4-one derivative, pharmaceutical composition, preparation method and application thereof | 长春金赛药业有限责任公司 | 2022-11-29 | — | — | CN | disclosed |