Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | GAA | P10253 | 3/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29211269 | 0.83 | KMT2A (0.34) | SMN1; SMN2LMNAKMT2ANUDT1ALDH1A1 | |
| SCHEMBL28896499 | 0.82 | SYK (0.38) | KDM4EMAPTL3MBTL1 | |
| SCHEMBL28896261 | 0.82 | KDM4E (0.34) | SMN1; SMN2LMNAKMT2ANUDT1ALDH1A1 | |
| SCHEMBL28896837 | 0.80 | SMN1; SMN2 (0.37) | SMN1; SMN2LMNAKMT2AALDH1A1GAA | |
| SCHEMBL28896253 | 0.77 | NUDT1 (0.38) | SMN1; SMN2LMNAKMT2ANUDT1ALDH1A1 | |
| SCHEMBL28896575 | 0.76 | LMNA (0.33) | SMN1; SMN2LMNAKMT2ANUDT1ALDH1A1 | |
| SCHEMBL24958271 | 0.73 | SMN1; SMN2 (0.44) | SMN1; SMN2LMNAKMT2ANUDT1ALDH1A1 | |
| SCHEMBL25241521 | 0.72 | KDM4E (0.51) | LMNAKMT2ANUDT1ALDH1A1GAA | |
| SCHEMBL4200796 | 0.72 | ALDH1A1 (0.45) | SMN1; SMN2LMNAKMT2ANUDT1ALDH1A1 | |
| SCHEMBL1492325 | 0.70 | KDM4E (0.50) | SMN1; SMN2LMNAKMT2ANUDT1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115403584-A | 2-thio-2, 3-dihydropyrimidine-4-one derivative, pharmaceutical composition, preparation method and application thereof | 长春金赛药业有限责任公司 | 2022-11-29 | — | — | CN | disclosed |